Tranexil 500 mg/5 ml (IM/IV Injection)

5 ml ampoule: ৳ 50.00 (1 x 5: ৳ 250.00)

Medicine Details

Category Details
Generic Tranexamic acid
Company Beximco pharmaceuticals ltd
Also available as
Tranexil 500 mg capsule

Product Title and Categories

  • Tranexil Antihemorrhagic Medicine
  • Medicine
  • Pharmaceuticals
  • Healthcare Products

Dimensions

  • N/A

Color Options

  • N/A

Functions

  • Prophylaxis of hemorrhagic syndromes
  • Therapy of hemorrhagic manifestations
  • Antifibrinolytic action
  • Promotes the formation of a fibrin capsule
  • Reduces bleeding during surgical interventions

Materials

  • Tranexamic Acid (trans-4 aminomethyl-cyclohexanecarboxylic acid)

Technical Specifications

  • 10 times more active than conventional hemostatics
  • Low acute toxicity
  • Well absorbed by oral route
  • Excreted mainly by renal route
  • Does not interfere with clotting processes
  • Low chronic toxicity

Design Elements

  • Ampoules (500 mg)
  • Capsules

Usability Features

  • Slow intravenous route administration
  • Oral administration
  • Storage at 15-30°C
  • Dry place storage
  • Away from light storage

Indications

  • Prophylaxis and therapy of hemophtoes
  • Prophylaxis and antihemorrhagic therapy during operations of any type and nature
  • Prophylaxis and antihemorrhagic therapy of prostatic, vesical and renal surgery
  • Prophylaxis and therapy of post-partum and puerperium hemorrhages
  • Prophylaxis and antihemorrhagic therapy during a tonsillectomy
  • Prophylaxis and antihemorrhagic therapy during maxillofacial operations

Pharmacology

  • Tranexamic acid is 10 times more active than conventional hemostatics
  • Has strong antifibrinolytic action
  • Low acute toxicity and chronic toxicity
  • Well absorbed by oral route
  • Excreted mainly by renal route
  • Does not interfere with clotting processes
  • No tendency to thrombophilia

Dosage & Administration

  • Usual adult dose: 500-1000 mg 3 times daily
  • Mean recommended daily doses for prophylaxis: 0.5-1 gm orally, 500 mg by parenteral route
  • For therapy of hemorrhagic manifestations, the oral dose increases to 1-3 gm given in divided doses
  • Oral administration for children: For every kg of body weight from 5-10 mg are orally administered daily in divided doses
  • No reduction in dosage for elderly patients unless evidence of renal failure

Interaction

  • Incompatible with solutions containing penicillins
  • Thrombolytic drugs like Streptokinase & Urokinase antagonise the antifibrinolytic action
  • Potential for thrombus formation may be increased by concomitant administration of estrogen-containing drugs
  • Direct admixture of Tranexil with whole blood should be avoided during transfusion

Contraindications

  • Known individual hypersensitivity to the product
  • Thromboembolic disease
  • Arterial and venous thrombosis
  • Endocavitary hemorrhages
  • Serious kidney failure

Side Effects

  • Sense of fatigue
  • Conjunctival irritation
  • Nasal blockage
  • Itching
  • Skin reddening
  • Exanthems
  • Nausea
  • Diarrhea
  • Gastric pyrosis
  • Postural hypotension

Pregnancy & Lactation

  • Tranexamic Acid should not be administered during known and presumed pregnancy
  • Passes into breast milk to a concentration of approximately one hundredth of the concentration in the maternal blood

Precautions & Warnings

  • Use in cases where there is hyperfibrinolysis
  • Prophylactic treatment must begin 24 hours before the operation and continue until 3-4 days after it
  • Therapy of hemorrhages must be prolonged for at least 24 hours after manifestations have disappeared
  • Reduce doses to prevent formation of clots in the urinary tract in hematuria
  • Avoid use in serious renal insufficiency or anuric syndromes
  • Particular care required in cardiopathic and hepatopathic subjects

Therapeutic Class

  • Anti-fibrinolytic drugs
  • Haemostatic drugs

Storage Conditions

  • Dry place at 15-30°C
  • Away from light
  • Keep out of children's reach

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