Esogel 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Esomeprazole
Company Novatek pharmaceuticals ltd
Also available as
Esogel 20 mg capsule Esogel 40 mg capsule Esogel 40 mg injection Esogel 40 mg tablet

Title

  • Esogel 20 mg Tablet

Categories

  • Medicine
  • Pharmaceutical

Description

  • Proton pump inhibitor for heartburn relief and other symptoms associated with GERD
  • Treatment for erosive esophagitis, duodenal & gastric ulcers, Zollinger-Ellison Syndrome, and acid-related dyspepsia
  • Eradication of Helicobacter pylori infection
  • Oral and IV administration

Color Options

    Function

    • Relief from chronic heartburn symptoms
    • Healing of erosive esophagitis
    • Maintenance of healing of erosive esophagitis
    • Eradication of Helicobacter pylori infection
    • Symptomatic relief for acid-related dyspepsia
    • Treatment for duodenal & gastric ulcers
    • Reduction of rebleeding of gastric or duodenal ulcers following therapeutic endoscopy
    • Reduction of stomach acid production

    Dosage Form

    • Tablet
    • Capsule
    • Oral Suspension
    • IV Injection
    • IV Infusion

    Dosage Administration

    • Oral: Swallow whole, taken one hour before a meal
    • Oral Suspension: Mixed with water, swallowed or administered through nasogastric or gastric tube
    • IV Injection: Intravenous administration over at least 3 minutes

    Dosage Recommendations

    • Healing of Erosive Esophagitis: 20 mg or 40 mg once daily for 4-8 weeks
    • Maintenance of Healing of Erosive Esophagitis: 20 mg once daily
    • Symptomatic GERD: 20 mg once daily for 4 weeks
    • Helicobacter Pylori eradication: Triple Therapy for 10 days
    • Zollinger-Ellison Syndrome: 20-80 mg once daily
    • Acid-related Dyspepsia: 20-40 mg once daily for 2-4 weeks
    • Duodenal Ulcer: 20 mg once daily for 2-4 weeks
    • Gastric Ulcer: 20-40 mg once daily for 4-8 weeks
    • IV Injection for Adult and Pediatric Patients

    Pharmacology

    • Mechanism of Action: Specific inhibition of H+/K+-ATPase in the gastric parietal cell
    • Absorption: Enteric-coated pellet formulation, peak plasma levels at approximately 1.5 hours after oral administration
    • Distribution: 97% bound to plasma proteins
    • Metabolism: Extensively metabolized by the CYP enzyme system
    • Excretion: Plasma elimination half-life of approximately 1-1.5 hours, less than 1% excreted unchanged in urine

    Interaction

    • Metabolized by CYP2C19 and CYP3A4
    • No clinically significant interactions with certain drugs identified
    • Potential interference with CYP2C19 and gastric pH-dependent drug absorption
    • Increased plasma levels when co-administered with certain drugs

    Contraindications

    • Known hypersensitivity to any of the formulation

    Side Effects

    • Headache
    • Diarrhea
    • Nausea
    • Flatulence
    • Abdominal pain
    • Constipation
    • Dry mouth

    Precautions

    • Symptomatic response to therapy does not preclude the presence of gastric malignancy
    • Instructions for patients with difficulty swallowing capsules
    • Use of antacids alongside Esogel
    • Specific advice for pregnant and breastfeeding individuals

    Special Populations

    • Pediatric Use: Safety and effectiveness not established
    • Geriatric Use: No overall differences in safety and efficacy observed
    • Hepatic Insufficiency: No dosage adjustment recommended for mild to moderate insufficiency
    • Renal Insufficiency: Pharmacokinetics not expected to be altered

    Overdose Effects

    • Acute toxicity symptoms observed in rats
    • No specific antidote known
    • Treatment should be symptomatic and supportive

    Storage Conditions

    Store at a temperature not exceeding 30°C, protect from light and moisture, keep out of reach of children

    Chemical Structure

    • Molecular Formula: C17H19N3O3S
    • Chemical Structure: Image link provided

    Pregnancy & Lactation

    • No adequate and well-controlled studies in pregnant women
    • No teratogenic effects noted in animal studies
    • Excretion in milk not studied, breastfeeding should be discontinued if essential

    Common Questions

    • Uses: Heartburn relief, GERD, ulcers, and erosive esophagitis
    • Side Effects: Headaches, diarrhea, nausea, gas, stomach pain, constipation, dry mouth
    • Pregnancy & Breastfeeding: Consultation with doctor recommended
    • Onset of Action: Usually within a few hours
    • Quick Tips:
      • Well-tolerated medicine
      • Avoid eating late at night
      • Inform doctor in case of specific symptoms
      • Long-term use may affect bone health
      • Consult doctor for specific medical conditions

    Indications

    • Relief from chronic heartburn symptoms
    • Healing of erosive esophagitis
    • Maintenance of healing of erosive esophagitis
    • Eradication of Helicobacter pylori infection
    • Treatment for Zollinger-Ellison Syndrome
    • Symptomatic relief for acid-related dyspepsia
    • Treatment for duodenal & gastric ulcers

    Administration

    • Oral: Swallowed whole
    • Oral Suspension: Mixed with water, swallowed or administered through nasogastric or gastric tube
    • IV Injection: Prepared with saline, administered intravenously over at least 3 minutes

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