Novetor 400 mg (Tablet)

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Doxophylline
Company Novatek pharmaceuticals ltd
Also available as
Novetor 200 mg tablet

Indications

  • Bronchial asthma
  • Bronchospasm
  • Chronic obstructive pulmonary disease (COPD)
  • Pulmonary disease with spastic bronchial component

Pharmacology

  • Doxophylline is a novel bronchodilator
  • Structurally differs from Theophylline due to the presence of a dioxolane group in position 7
  • Selectively inhibits phosphodiesterase 4 thereby relaxes bronchial smooth muscle
  • Reported to inhibit platelet activating factor (PAF) and generation of leukotriene production

Dosage & Administration

  • 200 mg tablet two or three times daily for elderly
  • 400 mg tablet two or three times daily for adults
  • 10 ml syrup or 200 mg tablet two or three times daily for >12 years of age children
  • 6-9 mg/kg body weight two times daily for 6-12 years of age children
  • Doxophylline SR tablet to be taken once daily if required daily dose is 400 mg

Interaction

  • Not to be administered with other xanthine preparations
  • Limit consumption of beverages and food containing caffeine
  • Exercise caution with ephedrine or other sympathomimetic drugs
  • Concurrent administration with erythromycin, TAO, lincomycin, clindamycin, allopurinol, cimetidine, influenza vaccine and propanolol should be done carefully

Contraindications

  • Known hypersensitivity to the drug or other xanthine derivatives
  • Acute myocardial infarction
  • Hypotension
  • Lactation

Side Effects

  • Nausea
  • Vomiting
  • Epigastric pain
  • Headache
  • Irritability
  • Insomnia
  • Tachycardia
  • Extrasystoles
  • Tachypnea
  • Hyperglycemia
  • Albuminuria
  • Severe cardiac arrhythmias
  • Tonic-clonic seizure

Pregnancy & Lactation

  • Effects during pregnancy should be evaluated carefully case by case on the basis of the risk-benefit ratio
  • Contraindicated during lactation
  • Does not interfere with ability to drive and use machines

Precautions & Warnings

  • Age, congestive cardiac decompensation, chronic obstructive pulmonary disease, severe liver disease, concomitant infections may reduce hepatic clearance
  • Monitoring of blood levels is recommended in cases of factors that influence the clearance of xanthine derivatives
  • Caution in administering to patients with cardiac disease, hypertension, elderly, severe hypoxemia, hyperthyroidism, chronic corpulmonale, congestive heart failure, liver disease, peptic ulcer, and renal impairment

Overdose Effects

  • Severe cardiac arrhythmias
  • Tonic-clonic seizure
  • Require discontinuation of the treatment
  • After symptoms of toxicity subside, treatment may be resumed at lower doses

Therapeutic Class

  • Bronchodilator
  • Methyl xanthine derivatives

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Related Brands