Xamic 500 mg/5 ml (IM/IV Injection)
5 ml ampoule: ৳ 55.00 (1 x 5: ৳ 275.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Tranexamic acid |
| Company | Renata limited |
| Also available as |
Title and Categories
- Xamic
- Medicine
- Hemostatic Drug
- Anti-Fibrinolytic Drug
Dosage and Administration
- Usual Dose: 500-1000 mg 3 times daily for adults
- Prophylaxis Dose: 0.5-1 gm orally, 500 mg by parenteral route
- Therapy of Hemorrhagic Manifestations: 1-3 gm given in divided doses for adults
- Dosing for Children based on body weight
- No reduction in dosage for elderly patients unless evidence of renal failure
Indications
- Prophylaxis and Therapy of Various Hemorrhagic Conditions in Medicine, Surgery, Urology, Obstetrics, Otorhinolaryngology, Stomatology, and Oncology
- Antihemorrhagic Therapy during Operations and Surgical Interventions
- Supportive Therapy in Oncology
- Prophylaxis and Therapy of Post-Partum and Puerperium Hemorrhages
- Prophylaxis and Antihemorrhagic Therapy for Tonsillectomy, Epistaxis, Maxillofacial Operations, Tooth Extractions, Prostatic, Vesical and Renal Surgery
Pharmacology
- Tranexamic Acid as the Active Ingredient with Strong Antifibrinolytic Action
- Inhibition of Plasminogen Activation
- Low Acute and Chronic Toxicity
- Well Absorbed Orally with Lasting Effect
- No Interference with Clotting Processes or Thrombophilia
Interaction
- Incompatibility with solutions containing penicillins
- Antagonism with Thrombolytic drugs like Streptokinase & Urokinase
- Potential for increased thrombus formation with concomitant administration of estrogen-containing drugs
- Avoid direct admixture with whole blood during transfusion
Contraindications
- Known Individual Hypersensitivity to the Product
- Thromboembolic Disease
- Arterial and Venous Thrombosis
- Endocavitary Hemorrhages
- Serious Kidney Failure
Side Effects
- Sense of Fatigue
- Conjunctival Irritation
- Nasal Blockage
- Itching
- Skin Reddening
- Exanthems
- Nausea
- Diarrhea
- Gastric Pyrosis
- Rare Cases of Postural Hypotension
- Hypersensitivity Reactions
Pregnancy & Lactation
- Avoid use during known and presumed pregnancy
- Passes into breast milk with unlikely antifibrinolytic effect in the infant
Precautions & Warnings
- Use in Hyperfibrinolysis cases
- Prophylactic treatment initiation before operation and continuation after it
- Prolonged therapy of hemorrhages even after manifestations have disappeared
- Caution in hematuria to prevent clot formation in urinary tract
- Avoid use in serious renal insufficiency or anuric syndromes, use with caution in less serious renal dysfunctions
- Particular care required in cardiopathic and hepatopathic subjects
Therapeutic Class
- Anti-Fibrinolytic Drugs
- Haemostatic Drugs
Storage Conditions
- Store in a dry place at 15-30°C
- Away from light
- Keep out of children's reach