Burn Free 1% (Cream)
25 gm tube: ৳ 35.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Silver sulfadiazine |
| Company | Albion laboratories limited |
Indications
- Topical prophylaxis against bacterial colonization in burn wounds
- Topical antibacterial management of contaminated wounds
Pharmacology
- Structural changes in bacterial cell membrane
- Distortion and enlargement of bacterial cell
- Weakening of cell wall membrane
- Reduction in viability of sensitive strains
- Binding of silver moiety to bacterial cells
- Inhibition of bacterial cell proliferation
- Bacteriostatic action against sensitive organisms
- Approximately 10% absorption in adults
- Approximately 60-85% excretion in urine
Dosage & Administration
- Cleansing of burn wounds before application
- Application thickness of approximately 1/16 inches or 1.5 mm
- Reapplication after patient activity or hydrotherapy
- Continued treatment until satisfactory healing
- Use of dressings if necessary
- Withdrawal in case of significant adverse reaction
Interaction
- Inactivation of enzymatic debriding agents
- Potentiation of oral hypoglycemic agents and phenytoin
- Increased incidence of leukopenia with cimetidine co-administration
Contraindications
- Hypersensitivity to the drug or its ingredients
- Pregnant women approaching or at term
- Premature infants
- Newborn infants during the first 2 months of life
Side Effects
- Transient leukopenia
- Skin necrosis
- Erythema multiform
- Skin discoloration
- Burning sensation
- Rashes
- Interstitial nephritis
Pregnancy & Lactation
- Pregnancy Category B
- Justified use during pregnancy
- Unknown excretion in human milk
- Consideration for discontinuation during nursing
- Safety and effectiveness not established for pediatric use
Precautions & Warnings
- Impaired hepatic and renal functions
- Possibility of inactivation of topical proteolytic enzymes
- Serum sulfa concentration monitoring
- Renal function and urine checks for sulfa crystals
Therapeutic Class
- Topical Antibiotic preparations
Storage Conditions
- Storage below 30 degree Celsius
- Protection from light & moisture
- Keep out of the reach of children