Domp 10 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Albion laboratories limited |
| Also available as |
Title
Domperidone 10 mg Tablet
Categories
- Medicine
- Pharmacology
- Gastrointestinal Health
Description
Domperidone 10 mg Tablet is a dopamine antagonist medication used to treat symptoms such as dyspepsia, nausea, vomiting, and delayed gastric emptying.
Manufacturer
Multiple manufacturers
Dosage form
Tablet, Oral Suspension, Suppository
Dosage strength
10 mg
Packaging options
- 30 tablets per bottle
- 100 ml suspension bottle
Color options
- White
- Yellow
Dimensions
10 mm x 5 mm x 3 mm
Weight
5 grams
Age group usage
Adults, Children
Administration route
Oral, Rectal
Active ingredient
Domperidone
Pharmacological class
Dopamine Antagonist
Therapeutic class
Motility Stimulants, Prokinetic drugs
Chemical structure
- Molecular formula: C22H24ClN5O2
- Image url: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Acute nausea and vomiting
- Parkinson's disease related nausea and vomiting
- Radiological studies speeding barium transit
Pharmacology
Blocks dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and stomach. Restores normal motility and tone of the upper gastrointestinal tract, facilitates gastric emptying, enhances antral and duodenal peristalsis, regulates contraction of the pylorus, increases esophageal peristalsis, and lower esophageal sphincter pressure.
Interaction
- Antagonistic drugs:
- Anticholinergic drugs
- Antacids antisecretory drugs: Should not be given simultaneously with domperidone
- Main metabolic pathway: CYP3A4
- Inhibitors examples:
- Azole antifungals
- Macrolide antibiotics
- HIV protease inhibitors
Contraindications
- Known hypersensitivity to domperidone
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction or perforation
- Prolactin releasing pituitary tumor (prolactinoma)
Side effects
- Common:
- Transient intestinal cramps
- Rare:
- Extrapyramidal phenomena
- Increased plasma prolactin level
- Rare allergic reactions like rash and urticaria
Pregnancy lactation
- Use during pregnancy: Only if justified by anticipated therapeutic benefit in the first trimester
- Breastfeeding: Not recommended unless benefits outweigh potential risk
Precautions warnings
- Children: Use with absolute caution due to risk of extra-pyramidal reactions
- Hepatic impairment: Use with caution
- Renal impairment: Consider dosing frequency reduction
Overdose effects
- Symptoms:
- Drowsiness
- Disorientation
- Extrapyramidal reactions
Storage conditions
Store below 30°C, Protected from light & moisture. Keep out of children's reach.
Usability warnings
Avoid driving or operating machinery if experiencing dizziness or sleepiness
Common questions
- Question: What is Domp 10 mg Tablet used for?
- Answer: To treat nausea and vomiting
- Question: Quick Tips
- Tips:
- Helps relieve nausea, vomiting and indigestion
- May cause dizziness and sleepiness
- Avoid consuming alcohol when taking
- Inform your doctor if severe side effects occur