Siligel 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Esomeprazole
Company Albion laboratories limited
Also available as
Esofour 20 mg tablet Esofour 40 mg tablet Siligel 20 mg capsule

Title

  • Siligel 40 mg Capsule

Categories

  • Medicine
  • Pharmaceuticals

Description

  • Proton pump inhibitor medication for treating GERD, erosive esophagitis, ulcers, and other acid-related conditions

Dosage Form

  • Oral tablets
  • Capsules
  • Oral suspension
  • IV injection

Dosage Instructions

  • 20 mg or 40 mg Once Daily for 4-8 Weeks for healing of erosive esophagitis
  • 20 mg Once Daily for Maintenance of Healing of Erosive Esophagitis
  • 20 mg Once Daily for Symptomatic GERD
  • 40 mg Once Daily for Helicobacter Pylori eradication
  • 20-80 mg Once Daily for Zollinger-Ellison Syndrome
  • 20-40 mg Once Daily for Acid-related Dyspepsia
  • 20 mg Once Daily for 2-4 weeks for Duodenal ulcer; 20-40 mg Once Daily for 4-8 weeks for Gastric ulcer

Administration Instructions

  • Tablets or capsules should be swallowed whole and taken one hour before a meal
  • Oral suspension should be mixed with water before consumption
  • IV Injection: Administered over a period of at least 3 minutes

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Excretion in breast milk not studied; Breast-feeding should be discontinued if essential

Precautions

  • Symptomatic response does not preclude presence of gastric malignancy
  • Usage instructions for patients
  • Use of antacids while taking the medication

Special Populations

  • Safety and effectiveness not established in pediatric patients
  • No overall differences in safety and efficacy observed between elderly and younger individuals

Overdose Effects

  • Acute toxicity in rats observed at high doses
  • No specific antidote known; Symptomatic and supportive treatment recommended

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Indications

  • Relief from chronic heartburn symptoms and symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor that suppresses gastric acid secretion
  • Peak plasma levels occur at approximately 1.5 hours after oral administration
  • Systemic bioavailability is approximately 90%
  • Metabolized in the liver by CYP enzymes
  • Plasma elimination half-life is approximately 1-1.5 hours

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • Not likely to inhibit certain CYP enzymes
  • May interfere with absorption of drugs where gastric pH is important
  • May increase plasma levels of certain drugs when co-administered

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Common Questions

  • Uses of Siligel 40 mg Capsule
  • Side effects
  • Pregnancy and breastfeeding considerations
  • Onset of action
  • Quick tips for usage

Mode of Action

  • Suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • First single optical isomer of proton pump inhibitor

Combination Therapy

  • Used in combination with amoxicillin and clarithromycin for eradication of Helicobacter pylori infection

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