Artigest 100 mg (Capsule)

Indications

• Maintenance of Pregnancy in cases of Threatened / Recurrent abortion
• Luteal support during IUI and ART procedures IVF-ET
• Luteal support in cases of proven luteal phase insufficiency
• Along with estrogen in post-menopausal hormone replacement therapy (HRT)
• To prevent endometrial hyperplasia where endogenous estrogen is present
• As progesterone challenge test in secondary amenorrhoea
• For cycle control along with estrogen therapy
• Dysfunctional uterine bleeding (DUB)
• Premenstrual tension
• Endometriosis
• Oocyte donation programme
• Benign mastopathy

Pharmacology

Contains micronised progesterone, which is structurally and biologically identical to natural endogenous progesterone. Micronisation increases bioavailability. Metabolized to pregnanediols and pregnanolones in the liver.

Dosage & Administration

• Usual recommended dose:
  • Progesterone 100 mg/200 mg 2 to 3 soft gel capsules daily by the oral or vaginal routes in divided doses
  • Flexible dosage regimen depending on indication and patient requirements
• Maintenance of Pregnancy in cases of Threatened / Recurrent abortion: Progesterone 200 to 400 mg per day in divided doses
• In-vitro fertilization and embryo transfer: Progesterone 200 mg thrice a day from the day of embryo transfer till pregnancy is confirmed. Continued till 12th week of pregnancy if pregnant
• HRT:
  • Sequential regimen: Progesterone 200mg daily for 12 days in last 2 weeks of each therapeutic cycle
  • Continuous regimen: Progesterone 100 mg daily throughout the month along with estrogen
• Oocyte donation program: Progesterone 100mg twice daily from the day of transfer till pregnancy is confirmed. Maximum of 600 mg per day and continued till 12th week of pregnancy
• Luteal support: Progesterone 100 mg thrice a day from the 17th day of the cycle for 10 days in induced cycle. Continued till 12th week of pregnancy if pregnant
• Luteal phase insufficiency: Progesterone 100 mg thrice daily to be continued up to 12 weeks of pregnancy, increasing the dose by 100 mg/day/week to a maximum of 600 mg/day in divided doses if required
• In secondary amenorrhoea: Progesterone 300mg for 10 days results in withdrawal bleeding in 80% of cases
• Premenstrual syndrome: Progesterone 100-200 mg daily for 10 days from 17th to 26th day of each menstrual cycle
• Benign mastopathy: Progesterone 200-300 mg for 10 days per month, usually from 17th to 26th day of the monthly cycle

Interaction

Ketoconazole inhibits the metabolism of progesterone

Contraindications

• Hypersensitivity
• Hepatic dysfunction
• Undiagnosed vaginal bleeding
• Porphyria
• Cancers of uterus and genital organs
• Breast cancers
• History of stroke or blood clots
• Miscarriage and tissue left in the uterus

Side Effects

Devoid of estrogenic, androgenic and mineralocorticoid effects. Some reported side effects include mild somnolence, depression, breast tenderness, and bloating. Side effects less when vaginal route is used.

Precautions & Warnings

• Severe renal insufficiency
• Diabetes mellitus
• Seizures
• Migraine
• Headache
• Heart diseases
• Depression

Therapeutic Class

Drugs for menopausal symptoms: Hormone replacement therapy, Female Sex hormones, Oral Contraceptive preparations

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children

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