Laxitab 1 mg (Tablet)
Unit Price: ৳ 14.00 (2 x 10: ৳ 280.00)
Strip Price: ৳ 140.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Prucalopride succinate |
| Company | Nipro jmi pharma ltd |
| Also available as |
Indications
- Symptomatic treatment of chronic constipation in adults
Pharmacology
- Selective stimulation of 5-HT4 receptors
- No interaction with hERG channel or 5-HT1 receptors
- Stimulation of propulsive motility
- Release of acetylcholine in the GI tract
- Contraction of muscle layer of the colon
- Relaxation of the circular muscle layer
Dosage & Administration
- 2 mg once daily for adults
- 1 mg once daily for older people
- Not recommended for children and adolescents
Interaction
- Low interaction potential with CYP-mediated metabolism
- Weak substrate for P-glycoprotein
- No clinically relevant effects on certain medications
Contraindications
- Hypersensitivity to active substance or excipients
- Renal impairment requiring dialysis
Side Effects
- Headache
- Gastrointestinal symptoms (abdominal pain, nausea, diarrhea)
Pregnancy & Lactation
- Not recommended during pregnancy
- Effective contraception recommended for women of childbearing potential
- Not recommended during breastfeeding
Precautions & Warnings
- Dose adjustment for severe renal impairment
- Caution in severe hepatic impairment
- Possible reduction in efficacy of oral contraceptives
- Contains lactose (not suitable for certain conditions)
Use in Special Populations
- Dose adjustment for severe renal impairment
- Dose adjustment for severe hepatic impairment
Overdose Effects
- Exaggeration of known pharmacodynamic effects
- Symptomatic treatment and supportive measures required
- Correction of electrolyte disturbances may be necessary
Therapeutic Class
- Osmotic purgatives
Storage Conditions
- Store at room temperature below 30°C
- Do not remove desiccant
- Dispense in original bottle