Prucalo 1 mg (Tablet)
Unit Price: ৳ 14.00 (3 x 10: ৳ 420.00)
Strip Price: ৳ 140.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Prucalopride succinate |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Symptomatic treatment of chronic constipation in adults
Pharmacology
- Selective stimulator of the 5-HT4 receptors
- Stimulates motility by interacting with 5-HT4 receptors
- Causes release of acetylcholine
- Propulsion of luminal content
Dosage & Administration
- Adults: 2 mg once daily with or without food
- Older people: Start with 1 mg once daily
- Children: Not recommended for use in children and adolescents younger than 18 years
Interaction
- Low interaction potential
- No clinically relevant effects on the pharmacokinetics of warfarin, digoxin, alcohol, paroxetine, or oral contraceptives
Contraindications
- Hypersensitivity to the active substance or excipients
- Renal impairment requiring dialysis
Side Effects
- Headache
- Gastrointestinal symptoms (abdominal pain, nausea, diarrhea)
- Majority of adverse events were mild to moderate in intensity
Pregnancy & Lactation
- Not recommended during pregnancy
- Women of childbearing potential should use effective contraception
- Not recommended during breastfeeding based on animal studies
Precautions & Warnings
- Dose adjustment in severe renal impairment
- Caution in severe hepatic impairment
- Possible reduction in efficacy of oral contraceptives with severe diarrhea
- Not suitable for patients with rare hereditary problems of galactose intolerance
Use in Special Populations
- Dose adjustment for severe renal impairment
- Dose adjustment for severe hepatic impairment
Overdose Effects
- Symptoms may include headache, nausea, and diarrhea
- No specific treatment available
- Treatment should be supportive and symptomatic
Therapeutic Class
- Osmotic purgatives
Storage Conditions
- Store at room temperature below 30°C
- Do not remove desiccant
- Dispense in original bottle