Restobac 25 mg (Tablet)

Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Baclofen
Company General pharmaceuticals ltd
Also available as
Restobac 10 mg tablet Restobac 5 mg tablet

Indications

  • spasticity resulting from multiple sclerosis
  • flexor spasms and concomitant pain, clonus and muscular rigidity
  • skeletal muscle spasm resulting from rheumatic disorders
  • spinal cord injuries and other spinal cord diseases
  • cerebrovascular accidents or neoplastic or degenerative brain disease

Pharmacology

  • inhibits both monosynaptic and polysynaptic reflexes
  • stimulates the GABA B receptors
  • inhibits the release of glutamate and aspartate
  • may produce CNS depression
  • exerts an antinociceptive effect

Dosage & Administration

  • 5 mg 3 times daily for adults & children over 10 years
  • gradually increased dosage
  • max. 100 mg daily for adults & children over 10 years
  • dosage varies for children under 10 years based on age
  • preferably taken with or after food

Interaction

  • Increased sedation with agents acting on the central nervous system, alcohol or synthetic opiates
  • Potentiation and increased fall in blood pressure when combined with antihypertensives
  • Pharmacological effects potentiation when combined with tricyclic antidepressants
  • Reports of mental confusion, hallucinations, headaches, nausea and agitation with concurrent use with levodopa and carbidopa
  • Increased CNS depressant effects with concurrent use of MAO inhibitors
  • Potential synergistic effect with magnesium sulphate or other neuromuscular blocking agents

Contraindications

  • Hypersensitivity to any component of the product

Side Effects

  • Transient drowsiness
  • Daytime sedation
  • Dizziness
  • Weakness
  • Fatigue
  • Various adverse reactions associated with the central nervous system, cardiovascular system, gastrointestinal system, genitourinary system, and others

Pregnancy & Lactation

  • Pregnancy category B3
  • Crosses the placental barrier
  • Should only be administered to pregnant women when potential benefits outweigh the possible hazards
  • Excreted in breast milk in small quantities with no expected undesirable effects on the infant

Precautions & Warnings

  • Lower doses for patients with impaired renal function or undergoing chronic hemodialysis
  • Cautious treatment for patients with psychotic disorders, schizophrenia, depressive or manic disorders
  • Possible lowering of the convulsion threshold in patients with epilepsy and muscle spasticity
  • Use with caution in patients with peptic ulcers, cerebrovascular diseases, or hepatic, renal or respiratory failure
  • Essential monitoring of respiratory and cardiovascular function, especially in patients with cardiopulmonary disease and respiratory muscle weakness
  • Possibility of acute retention of urine in patients with preexisting sphincter hypertonia
  • Limited benefit and poor tolerance in stroke patients

Overdose Effects

  • Importance of gastric lavage in case of severe overdose

Therapeutic Class

  • Centrally acting Skeletal Muscle Relaxants

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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