Tizalex 2 mg (Tablet)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tizanidine hydrochloride |
| Company | Apex pharmaceuticals ltd |
Indications
- Treatment of painful muscle spasms
- Associated with static and functional disorders of the spine (cervical and lumbar syndromes)
- Following surgery, e.g. for herniated intervertebral disc or osteoarthritis of the hip
- Treatment of spasticity due to neurological disorders
- Multiple sclerosis
- Chronic myelopathy
- Degenerative spinal cord diseases
- Cerebrovascular accidents
- Cerebral palsy
Pharmacology
- Centrally acting skeletal muscle relaxant
- Principal site of action is the spinal cord
- Stimulates presynaptic alpha2 receptors
- Inhibits release of excitatory amino acids
- Inhibits polysynaptic signal transmission at spinal interneuron level
- Moderate central analgesic effect
- Effective in acute painful muscle spasms and chronic spasticity
- Reduces resistance to passive movements
- Alleviates spasms and clonus
- May improve voluntary strength
- Antispastic activity
Dosage & Administration
- Narrow therapeutic index
- High inter-patient variability in plasma concentrations
- Initial dose of 2 mg three times daily
- Relief of painful muscle spasms: 2 to 4 mg three times daily
- Spasticity due to neurological disorders: initial daily dose not to exceed 6 mg
- Usual daily dose of 12 to 24 mg
- Maximum daily dose of 36 mg
- Discontinuation requires slow down titration
Interaction
- Concomitant administration with CYP1A2 inhibitors may increase plasma levels
- Concomitant administration with CYP1A2 inducers may decrease plasma levels
- Contraindicated with fluvoxamine or ciprofloxacin
- Caution with drugs known to prolong the QT interval
- Potential interactions with antihypertensives, rifampicin, cigarette smoke, alcohol, sedatives, and hypnotics
Contraindications
- Known hypersensitivity to tizanidine or excipients
- Severely impaired hepatic function
- Concomitant use with strong CYP1A2 inhibitors
Side Effects
- Somnolence
- Fatigue
- Dizziness
- Hypotension
- Bradycardia
- Muscular weakness
- Insomnia
- Dry mouth
- Nausea
- Gastrointestinal disorder
- Transaminase increase
- Hallucination
- Hepatitis
Pregnancy & Lactation
- Limited experience in pregnant women
- Animal studies showed increased gestation duration
- Small amounts excreted in rat milk
- Contraindicated in breastfeeding women
- Sexually-active females should use effective contraception
- No impairment of fertility in animal studies
Precautions & Warnings
- Caution with CYP inhibitors and drugs known to increase the QT interval
- Risk of hypotension
- Potential withdrawal syndrome
- Monitoring of liver function tests
- Increased systemic exposure in renal impairment
- Hypersensitivity reactions
- Recommendation to refrain from driving or using machines
Use in Special Populations
- Maximal mean plasma levels higher in renal impairment
- No specific studies in hepatic impairment
- Limited pharmacokinetic data in geriatrics
- No clinically significant effect of gender
Overdose Effects
- Reports of uneventful recovery
- Symptoms may include nausea, vomiting, hypotension, QT prolongation, dizziness, somnolence, miosis, restlessness, respiratory distress, coma
- Recommendation for symptomatic treatment
Therapeutic Class
- Centrally acting Skeletal Muscle Relaxants
Storage Conditions
- Store in a dry place below 30°C
- Keep out of reach and sight of children