Fenocap 200 mg (Capsule)

Indications

• Hyperlipidemias of type lla, llb, III, IV & V

Pharmacology

• Fenofibrate is a fibric acid derivative
• Reductions in total cholesterol, LDL cholesterol, Apo-lipoprotein B
• Increases in HDL and apo-proteins apoAI apoAII
• Reduces serum uric acid levels

Dosage & Administration

• Initial dose of 200 mg per day for hypercholesterolemia or mixed hyperlipidemia in adults
• Initial dose of 67 to 200 mg per day for hypertriglyceridemia in adults
• Dose should be individualized according to patient response
• Should be given with a meal for optimal bioavailability

Interaction

• Potentiates the anticoagulant effects of warfarin
• May improve glucose tolerance and have additive effect when administered with antidiabetic drugs
• May increase the nephrotoxicity of cyclosporine
• Cautions should be taken against the use with HMG-CoA reductase inhibitors (statins)

Contraindications

• Hypersensitivity to Fenofibrate
• Severe renal or hepatic impairment
• Existing gall bladder disease
• Breastfeeding mothers
• Photosensitivity to ketoprofen

Side Effects

• Gastro-intestinal issues (nausea, anorexia, gastric pain)
• Pruritus
• Urticaria
• Impotence
• Headache
• Dizziness
• Vertigo
• Fatigue
• Hair loss
• Myotoxicity

Pregnancy & Lactation

• Not recommended for pregnant women

Precautions & Warnings

• Special care needed in patients with renal disease
• Discontinue if myotoxicity suspected or creatinine kinase concentration increases significantly
• Liver function tests recommended every 3 months for the first year

Overdose Effects

• No specific treatment for overdose with Fenocap
• General supportive care indicated
• Hemodialysis should not be considered due to high plasma protein binding

Therapeutic Class

• Fibrates

Storage Conditions

• Do not store above 30°C
• Keep away from light and out of the reach of children

Related Brands

• Fenatrol 145 mg (Tablet) - drug-international-ltd