S-Ome 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Esomeprazole
Company Somatec pharmaceuticals ltd
Also available as
S ome 20 mg tablet S ome 40 mg tablet S ome 20 mg capsule

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Enteric-coated pellet formulation
  • Peak plasma levels occur at approximately 1.5 hours after oral administration
  • 97% bound to plasma proteins
  • Extensively metabolized in the liver by the cytochrome P450 enzyme system
  • Plasma elimination half-life of approximately 1-1.5 hours
  • Systemic bioavailability is approximately 90% after repeated once daily dosing

Dosage

  • 20 mg or 40 mg Once Daily for 4-8 Weeks for healing of erosive esophagitis
  • 20 mg Once Daily for maintenance of healing of erosive esophagitis
  • 20 mg Once Daily for symptomatic GERD
  • Triple Therapy for Helicobacter pylori eradication: Esomeprazole 40 mg Once Daily for 10 days, Amoxicillin 1000 mg Twice Daily for 10 days, Clarithromycin 500 mg Twice Daily for 10 days
  • 20-80 mg once daily for Zollinger-Ellison Syndrome
  • 20-40 mg once daily for Acid-related Dyspepsia for 2-4 weeks according to the response
  • 20 mg once daily for 2-4 weeks for Duodenal ulcer and 20-40 mg once daily for 4-8 weeks for Gastric ulcer
  • Dosage adjustment for pediatric and adult patients receiving IV Injection or IV infusion
  • 80 mg for risk reduction of rebleeding of Gastric or Duodenal Ulcers following therapeutic endoscopy in adults

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension should be taken with water and stirred well before consumption
  • IV Injection: Solution for injection prepared with 0.9% Sodium Chloride should be administered intravenously over a period of at least 3 minutes
  • Specific instructions for administration through a nasogastric or gastric tube

Interaction

  • No clinically relevant interactions with drugs metabolized by several CYP enzymes
  • Potential interference with absorption of drugs where gastric pH is important for bioavailability
  • Increased plasma levels of diazepam observed with co-administration

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Frequently occurring adverse events include headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies have revealed no teratogenic effects
  • Excretion of esomeprazole in milk not studied, breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Instructions for patients with difficulty swallowing capsules
  • Use of antacids while taking S-Ome

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients
  • No overall differences in safety and efficacy observed between elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • No alteration in pharmacokinetics expected in patients with renal impairment

Overdose Effects

  • Acute toxicity signs include reduced motor activity, respiratory changes, tremor, and convulsions
  • No specific antidote known, treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image URL: (URL)

Common Questions about S-Ome 40 mg Capsule

  • Medication overview
  • Multiple uses and indications
  • Side effects clarification
  • Pregnancy and breastfeeding considerations
  • Onset of action and quick tips for usage

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