Empadi-M 5 mg+500 mg (Tablet)
Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | Pacific pharmaceuticals ltd |
Indications
- Treatment of adults with type 2 diabetes mellitus
- Adjunct to diet and exercise
- Combination therapy with other medicinal products for diabetes
Pharmacology
- Inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Reduces renal reabsorption of glucose
- Lowers renal threshold for glucose
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized based on effectiveness and tolerability
- Take twice daily with meals
- Gradual dose escalation to reduce gastrointestinal side effects
- Maximum recommended daily doses of Metformin Hydrochloride and Empagliflozin
- Extended-release formulation available
Interaction
- Diuretics
- Insulin or Insulin Secretagogues
- Positive Urine Glucose Test
- Drugs that Reduce Metformin Clearance
- Carbonic Anhydrase Inhibitors
- Drugs Affecting Glycemic Control
- Alcohol
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
- Hepatic impairment
- Acute alcohol intoxication
- Alcoholism
Side Effects
- Urinary tract infection
- Female genital mycotic infections
- Diarrhea
- Nausea/vomiting
- Flatulence
- Abdominal discomfort
- Indigestion
- Asthenia
- Headache
- Hypoglycemia
- Vaginal moniliasis
- Urinary tract infection
- Increased urination
- Serum lipids increased
- Lactic acidosis
Pregnancy & Lactation
- Potential risk to fetus
- Not recommended during breastfeeding
Precautions & Warnings
- Lactic Acidosis
- Hypotension
- Ketoacidosis
- Acute kidney injury & impairment in renal function
- Urosepsis, Pyelonephritis, Fournier’s gangrene & Genital mycotic infections
- Hypoglycemia
- Vitamin B12 Deficiency
- Increased LDL-C
- Macrovascular Outcomes
Overdose Effects
- No toxicity observed at high single or multiple doses of Empagliflozin
- Hypoglycaemia not seen with Metformin doses up to 85 g
- Lactic acidosis is a medical emergency
- Treatment should be initiated based on clinical status
- Haemodialysis for removal of lactate and Metformin
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Keep below 30°C
- Protected from light & moisture
- Keep out of the reach of children