Epoetin 10000 IU (IV/SC Injection)

10000 IU pre-filled syringe: ৳ 3,800.00

Medicine Details

Category Details
Generic Erythropoietin alfa
Company Incepta pharmaceuticals ltd
Also available as
Epoetin 2000 iu injection Epoetin 3000 iu injection Epoetin 5000 iu injection Epoetin 4000 iu injection

Title

  • Epoetin Alfa Recombinant Drug

Categories

  • Medicine
  • Pharmaceutical
  • Anemia Treatment

Description

  • Recombinant human erythropoietin (EPO)
  • 165 amino acid sequence identical to that of human urinary EPO
  • Apparent molecular weight of erythropoietin is about 30,400 daltons

Indications

  • Treatment of anemia due to Chronic Kidney Disease (CKD) in patients on dialysis and not on dialysis
  • Treatment of anemia due to Zidovudine in HIV-infected patients
  • Reduction of allogeneic RBC transfusions in patients undergoing elective, noncardiac, nonvascular surgery
  • Prevention of anemia of prematurity in infants with a birth weight of 750 to 1500 gm and gestational age of less than 34 weeks

Dosage

  • Evaluation of iron stores and nutritional factors before and during treatment
  • Monitoring hemoglobin levels at least weekly until stable, then monitor at least monthly
  • Adjusting therapy based on hemoglobin rate of rise, rate of decline, ESA responsiveness, and hemoglobin variability
  • Initiating treatment when hemoglobin level is less than 10 g/dL in CKD patients on dialysis
  • Initiating treatment when hemoglobin level is less than 10 g/dL in CKD patients not on dialysis
  • Starting dose recommendations for adult and pediatric patients
  • Dose adjustment based on the response

Interaction

  • Potentiation of Epoetin effect by simultaneous therapeutic administration of a haematinic agent such as ferrous sulphate

Contraindications

  • Uncontrolled hypertension
  • Serious allergic reactions to Erythropoietin alfa
  • Patients who develop Pure Red Cell Aplasia (PRCA) following treatment with any erythropoietin

Side Effects

  • Adverse reactions in 5% of Epoetin treated patients in clinical studies
  • Variety of side effects observed in different patient groups

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Reproduction toxicology observed in animal studies
  • Caution advised for use in pregnancy and lactation

Overdose Effects

  • Wide therapeutic margin of Epoetin
  • Possible management with discontinuation or reduction of dosage and/or with phlebotomy
  • Cases of severe hypertension observed following overdose with ESAs

Therapeutic Class

  • Drugs for Haemolytic Hypoplastic & Renal Anemia

Storage Conditions

  • Store at 2°C to 8°C
  • Do not freeze or shake
  • Original package storage to protect from light

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