Osikin 80 mg (Tablet)
Unit Price: ৳ 425.00 (1 x 10: ৳ 4,250.00)
Strip Price: ৳ 4,250.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Osimertinib |
| Company | Ziska pharmaceuticals ltd |
Indications
- First-line treatment of metastatic non-small cell lung cancer (NSCLC)
- Treatment of patients with metastatic EGFR T790M mutation-positive NSCLC
- Treatment of patients with tumors having EGFR exon 19 deletions or exon 21 L858R mutations
Pharmacology
- Kinase inhibitor of the epidermal growth factor receptor (EGFR)
- Binds irreversibly to mutant forms of EGFR
- Exhibits anti-tumor activity against NSCLC lines harboring EGFR mutations
- Inhibits activity of HER2, HER3, HER4, ACK1, BLK
- Linear pharmacokinetics (PK)
Dosage & Administration
- Recommended dose: 80 mg tablet once a day
- Can be taken with or without food
- Disperse tablet in 60 ml of non-carbonated water
- Do not crush, heat, or ultrasonicate during preparation
Interaction
- Avoid concomitant administration with strong CYP3A inhibitors
- Avoid concomitant administration with strong CYP3A inducers
- Effect on other drugs: avoid concomitant administration with drugs that are sensitive substrates of CYP3A, BCRP, or CYP1A2
Side Effects
- Most common adverse reactions: diarrhea, rash, dry skin, nail toxicity, stomatitis, fatigue, decreased appetite
Pregnancy & Lactation
- Can cause fetal harm when administered to a pregnant woman
- Advise females of reproductive potential to use effective contraception during treatment
- Effects on infertility based on animal studies
Precautions & Warnings
- Interstitial Lung Disease (ILD)/Pneumonitis occurred in 3.9% of Osikin-treated patients
- Monitor electrocardiograms and electrolytes for QTc prolongation
- Assess left ventricular ejection fraction before treatment
- Advise females to use effective contraception during treatment
Use in Special Populations
- No clinically significant differences based on age, sex, ethnicity
- No established safety and effectiveness in pediatric patients
- No overall differences in effectiveness based on age
- No dose adjustment recommended in patients with mild, moderate or severe renal impairment
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store below 30°C
- Protect from moisture & light
- Keep out of the reach of children