Gefikin 250 mg (Tablet)

Unit Price: ৳ 250.00 (4 x 7: ৳ 7,000.00)
Strip Price: ৳ 1,750.00

Medicine Details

Category Details
Generic Gefitinib
Company Ziska pharmaceuticals ltd

Indications

  • First-line treatment for metastatic non-small cell lung cancer
  • Patients with EGFR exon 19 deletions or exon 21 (L858R) substitution mutations
  • Detectable by FDA-approved test

Pharmacology

  • Reversibly inhibits kinase activity of wild-type and certain activating mutations of EGFR
  • Prevents autophosphorylation of tyrosine residues
  • Blocks EGFR-dependent proliferation
  • Inhibits IGF and PDGF-mediated signalling
  • Higher binding affinity for EGFR mutations than wild-type EGFR

Dosage & Administration

  • Recommended dose: 250 mg orally once daily
  • Can be taken with or without food
  • Do not take a missed dose within 12 hours of the next dose
  • For patients with difficulty swallowing solids: tablets can be immersed in water and administered

Interaction

  • CYP3A4 inducers increase metabolism and decrease plasma concentrations
  • CYP3A4 inhibitors decrease metabolism and increase plasma concentrations

Contraindications

  • Known hypersensitivity to Gefitinib or any other components of the drug

Side Effects

  • Interstitial Lung Disease
  • Hepatotoxicity
  • Gastrointestinal Perforation
  • Severe or Persistent Diarrhea
  • Ocular Disorders including Keratitis
  • Bullous and Exfoliative Skin Disorders

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Potential hazard to the fetus or risk for loss of the pregnancy
  • Unknown excretion in human milk
  • Discontinue breastfeeding during treatment

Precautions & Warnings

  • ILD-like adverse drug reactions occurred in 1.3% of patients
  • Prompt investigation for ILD in case of worsened respiratory symptoms
  • Periodic liver function testing required
  • Discontinue in case of severe hepatic impairment or gastrointestinal perforation
  • Withhold for severe or persistent diarrhea or ocular disorders

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • Monitor adverse reactions in patients with renal or hepatic impairment

Therapeutic Class

  • Targeted Cancer Therapy

Storage Conditions

  • Store between 20-25°C
  • Store in a cool and dry place away from sunlight
  • Keep out of the reach of children

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