Folinic 5 mg (Tablet)

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)

Strip Price: ৳ 90.00

Medicine Details

Category	Details
Generic	Folinic acid
Company	Renata limited

Neutralising the immediate toxic effects of folic acid antagonists, e.g. methotrexate
Calcium folinate rescue- a treatment technique using calcium folinate in conjunction with folic acid antagonists, e.g. methotrexate, to minimise systemic toxicity
The treatment of megaloblastic anaemias due to sprue, nutritional deficiency, pregnancy, infancy, liver disease and malabsorption syndrome

Each tablet contains Calcium Folinate Hydrate BP 6.249 mg equivalent to Folinic Acid 5 mg
Each tablet contains Calcium Folinate Hydrate BP 18.746 mg equivalent to Folinic Acid 15 mg

Preparation of Calcium Folinate Hydrate which is calcium salt of folinic acid (5-formyl derivative of tetrahydrofolic acid)
Metabolite and active form of folic acid
Involvement as a cofactor for 1-carbon transfer reactions in the biosynthesis of purine and pyrimidines of nucleic acids
Potent antidote for both hematopoietic and reticuloendothelial toxic effects of folic acid antagonists
Ready conversion to other tetrahydrofolic acid derivatives
Basis of high-dose methotrexate therapy with 'Folinate rescue'

Calcium folinate rescue should begin as soon as possible after an inadvertent overdosage and within 24 hours of methotrexate administration when there is delayed excretion
No fixed guidelines regarding the dose of methotrexate that triggers an automatic subsequent Folinic Acid administration
Dosage regimens vary depending upon the dose of methotrexate administered
Folinic Acid should be administered at a dose of 15 mg (approximately 10 mg/m2) every 6 hours for 10 doses
Recommended dose of Folinic Acid to counteract hematologic toxicity from folic acid antagonists with less affinity for mammalian dihydrofolate reductase than methotrexate is substantially less
5 mg to 15 mg of Folinic Acid per day for megaloblastic anaemia (folate deficiency)
Safety and efficacy of folinic acid in children and adolescents have not been established

Folinates given in large amounts may counteract the antiepileptic effect of phenobarbitone, phenytoin and primidone
Increase the frequency of seizures in susceptible patients
Caution required during concurrent administration of calcium folinate with fluoropyrimidine

Known hypersensitivity to calcium folinate or any other components of this product
Pernicious anemia or other megaloblastic anemia where vitamin B12 is deficient
Rare hereditary problems of galactose intolerance, the lapp lactase deficiency or glucose-galactose malabsorption

No adequate and well-controlled clinical studies conducted in pregnant women
Use in pregnant women only if the potential benefit justifies the potential risk to the fetus
Unknown excretion in human milk
Caution should be exercised when calcium folinate is administered to a nursing mother

Use with methotrexate or 5-FU under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents
Treatment of inadvertent overdosage of a folic acid antagonist
Prompt excretion of methotrexate as part of Calcium Folinate Rescue Therapy
General avoidance of simultaneous administration with folic acid antagonists
Measurement of plasma methotrexate concentration, BUN and creatinine

No reported sequelae in patients who have received significantly more calcium folinate than the recommended dosage
Excessive amounts may nullify the chemotherapeutic effect of folic acid antagonists
No specific antidote to calcium folinate overdose
Appropriate supportive care for cases of overdosage