Pirfedone 267 mg (Tablet)
Unit Price: ৳ 45.00 (5 x 6: ৳ 1,350.00)
Strip Price: ৳ 270.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pirfenidone |
| Company | Renata limited |
| Also available as |
Indications
- Treatment of mild to moderate Idiopathic Pulmonary Fibrosis (IPF)
Pharmacology
- Anti-inflammatory properties
- Antioxidant properties
- Anti-fibrotic properties
- Improvement of lung function
- Reduction of acute exacerbations
- Suppression of TGF-β1
- Downregulation of pro-inflammatory cytokines
- Inhibition of inflammatory cells
- Inhibition of increased pulmonary vascular permeability
Dosage & Administration
- Oral administration with food
- Initial titration period
- Recommended daily dose of nine 267 mg tablets or three 801 mg tablets
- Dose adjustments for gastrointestinal events
- Dose adjustments for photosensitivity reaction or rash
- Dose adjustments for hepatic function
Interaction
- Moderate and strong CYP1A2 inhibitors
- Adverse reactions alteration with concomitant use of specific medicines
- Reduced adverse reactions with food intake
Contraindications
- Hypersensitivity to the active substance or excipients
- Concomitant use of fluvoxamine
- Severe hepatic impairment or end stage liver disease
- Severe renal impairment or end stage renal disease requiring dialysis
Side Effects
- Common: nausea, rash, abdominal pain, upper respiratory tract infection, diarrhea, fatigue, headache, dyspepsia, dizziness, vomiting, anorexia, gastroesophageal reflux disease, sinusitis, insomnia, weight decrease, arthralgia
- Rare: photosensitivity reaction, decreased appetite, pruritus, asthenia, dysgeusia, non-cardiac chest pain
Pregnancy & Lactation
- Precautionary avoidance during pregnancy
- Unknown excretion in human milk
- No effects on fertility and reproductive performance in animal studies
Precautions & Warnings
- Monitoring of liver enzymes
- Avoidance of sunlight and sunlamps
- Monitoring and consideration of dosage modifications for gastrointestinal disorders
Use in Special Populations
- Unknown safety and efficacy in children & adolescents
- Consideration of dosage modification or discontinuation for hepatic impairment and renal impairment
- Decreased exposure in smokers
Overdose Effects
- Limited clinical experience with overdose
- Mild, transient adverse reactions observed with high doses in healthy adult volunteers
Therapeutic Class
- Immunosuppressant
Storage Conditions
- Cool & dry storage
- Protection from light & moisture
- Keep out of reach of children