Pulmobi 801 mg (Tablet)
Unit Price: ৳ 125.00 (2 x 10: ৳ 2,500.00)
Strip Price: ৳ 1,250.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pirfenidone |
| Company | Biopharma limited |
| Also available as |
Indications
- Treatment of mild to moderate Idiopathic Pulmonary Fibrosis (IPF) in adults
Pharmacology
- Anti-inflammatory
- Antioxidant
- Anti-fibrotic properties
- Improves lung function
- Reduces acute exacerbations in patients with IPF
- Inhibits TGF-β1
- Downregulates pro-inflammatory cytokines
Dosage & Administration
- Route of administration: Oral with food
- Recommended daily dose: Nine 267 mg tablets or three 801 mg tablet per day for IPF patients
- Titration schedule
- Dose adjustments for gastrointestinal events, photosensitivity reaction, or rash
- Dose adjustment for hepatic function
Interaction
- With medicine: Moderate and strong CYP1A2 inhibitors
- With food and others: Reduced adverse reactions when taken with food
Contraindications
- Hypersensitivity to active substance or excipients
- Concomitant use of fluvoxamine
- Severe hepatic impairment or end stage liver disease
- Severe renal impairment or end stage renal disease requiring dialysis
Side Effects
- Common: Nausea, rash, abdominal pain, upper respiratory tract infection, diarrhea, fatigue, headache, dyspepsia, dizziness, vomiting, anorexia, gastroesophageal reflux disease, sinusitis, insomnia, weight decrease, arthralgia
- Rare: Photosensitivity reaction, decreased appetite, pruritus, asthenia, dysgeusia, non-cardiac chest pain
Pregnancy & Lactation
- Preferable to avoid use during pregnancy
- Unknown excretion in human milk
- No effects on fertility and reproductive performance in rats at dosages up to 1000 mg/kg/day
Precautions & Warnings
- Monitor elevated liver enzymes
- Avoid photosensitivity and rash
- Monitor gastrointestinal disorders
- Use in Special Populations
Use in Special Populations
- Safety and efficacy not known in children & adolescents
- Monitoring and dosage modification for hepatic impairment
- Monitoring and dosage modification for renal impairment
- Decreased exposure noted in smokers
Overdose Effects
- Limited clinical experience with overdose
- Mild, transient adverse reactions observed with multiple doses up to 4806 mg/day
Therapeutic Class
- Immunosuppressant
Storage Conditions
- Cool, dry place
- Protection from light & moisture
- Keep out of reach of children