Fenidone 267 mg (Tablet)
Unit Price: ৳ 45.00 (3 x 10: ৳ 1,350.00)
Strip Price: ৳ 450.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pirfenidone |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild to moderate Idiopathic Pulmonary Fibrosis (IPF) in adults
Pharmacology
- Anti-inflammatory properties
- Antioxidant properties
- Anti-fibrotic properties
- Improvement of lung function
- Reduction of acute exacerbations in IPF patients
- Suppression of TGF-β1
- Downregulation of pro-inflammatory cytokines (e.g., TNF-α, interleukin-1, interferon-gamma)
Dosage & Administration
- Oral route of administration
- Recommended daily dose of nine 267 mg tablets or three 801 mg tablets per day
- Titration period for initiating treatment
- Dose adjustments for gastrointestinal events
- Dose adjustments for photosensitivity reaction or rash
- Dose adjustments for hepatic function
- Re-initiation of therapy after treatment interruption
Interaction
- Moderate and strong inhibitors of CYP1A2 affect systemic exposure
- Consider dose reduction with certain medications
- Reduced incidence of adverse reactions observed with food intake
Contraindications
- Hypersensitivity to the active substance or excipients
- Concomitant use of fluvoxamine
- Severe hepatic impairment or end stage liver disease
- Severe renal impairment (CrCl < 30 ml/min) or end stage renal disease requiring dialysis
Side Effects
- Common: nausea, rash, abdominal pain, upper respiratory tract infection, diarrhea, fatigue, headache, dyspepsia, dizziness, vomiting, anorexia, gastroesophageal reflux disease, sinusitis, insomnia, weight decrease, arthralgia
- Rare: photosensitivity reaction, decreased appetite, pruritus, asthenia, dysgeusia, non-cardiac chest pain
Pregnancy & Lactation
- Limited data on use in pregnant women
- Potential placental transfer of pirfenidone in animals
- Preferable to avoid use during pregnancy
- Unknown excretion of pirfenidone in human milk
- Potential excretion of pirfenidone in milk in animals
- Considerations in decision-making for breast-feeding and therapy
Precautions & Warnings
- Monitoring of liver enzymes
- Precautions for photosensitivity and rash
- Monitoring and considerations for gastrointestinal disorders
- Use in Special Populations: Children & Adolescents, Hepatic Impairment, Renal Impairment, Smokers
Use in Special Populations
- Safety and efficacy in children & adolescents not established
- Considerations for patients with hepatic impairment
- Considerations for patients with renal impairment
- Altered exposure in smokers
Overdose Effects
- Limited clinical experience with overdoses
- Experiences with multiple doses up to 4806 mg/day
Therapeutic Class
- Immunosuppressant
Storage Conditions
- Cool and dry storage
- Protection from light and moisture
- Keep out of reach of children