Lofat 200 mg (Capsule)
Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Fenofibrate |
| Company | Beximco pharmaceuticals ltd |
Indications
- Indicated for hyperlipidemias of type Ila, IIb, III, IV & V
- For patients who have not responded adequately to diet & other measures
Pharmacology
- Fenofibrate is a fibric acid derivative
- Rapidly hydrolyzed after oral ingestion to its pharmacologically active form, fenofibric acid
- Produces reductions in total cholesterol, LDL cholesterol, Apo-lipoprotein B, Total triglycerides and VLDL
- Increases in HDL and apo-proteins apoAI apoAII
- Reduces serum uric acid levels
- Micronised form has enhanced absorption over the non-micronised formulation
Dosage & Administration
- Initial dose of Fenofibrate is 200 mg per day for adult patients with hypercholesterolemia or mixed hyperlipidemia
- For adult patients with hypertriglyceridemia, the initial dose is 67 to 200 mg per day
- Dose should be individualized according to patient response
- Fenofibrate should be given with meal to optimize bioavailability
Interaction
- Potentiates the anticoagulant effects of warfarin
- May improve glucose tolerance and have additive effect when administered with antidiabetic drug
- May increase the nephrotoxicity of cyclosporine
- Cautions should be taken against the use of HMG-CoA reductase inhibitors
Contraindications
- Hypersensitivity to Fenofibrate
- Severe renal or hepatic impairment
- Existing gall bladder disease
- Breastfeeding mothers
- Photosensitivity to ketoprofen
Side Effects
- Gastrointestinal issues such as nausea, anorexia, gastric pain
- Pruritus, urticaria, impotence
- Headache, dizziness, vertigo, fatigue, hair loss
- Myotoxicity
Pregnancy & Lactation
- Not recommended for pregnant women
Precautions & Warnings
- Special care needed in patients with renal disease
- Discontinue if myotoxicity suspected or creatinine kinase concentration increases significantly
- Liver function tests recommended every 3 months for first year
Overdose Effects
- No specific treatment for overdose
- General supportive care indicated
- Hemodialysis should not be considered
Therapeutic Class
- Fibrates
Storage Conditions
- Do not store above 30°C
- Keep away from light
- Keep out of the reach of children