Hypnofast 5 mg/5 ml (IM/IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Midazolam |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Short-term treatment of insomnia
- Sedation in premedication before surgical or diagnostic procedures
Description
Sleep-inducing agent characterized by rapid onset and short duration of action, exerts anxiolytic, anticonvulsant and muscle-relaxant effect
Pharmacology
Actions mediated through the inhibitory neurotransmitter GABA, increase GABA activity producing sedating effect, relaxing skeletal muscles, and inducing sleep, anesthesia, and amnesia
Dosage & Administration
- Oral dosage for adults: 7.5-15 mg daily
- Oral dosage in elderly and debilitated patients: 7.5 mg
- IV administration for endoscopic or cardiovascular procedures: Approximately 2.5 mg for healthy adults, reduced to 1 to 1.5 mg for severe illness and elderly patients
- IV administration for induction of anesthesia: 10-15 mg
- Intramuscular administration for adults: 0.07-0.1 mg/kg body weight, usual dose about 5 mg
- Intramuscular administration for children: 0.15-0.20 mg/kg
- Intramuscular administration for elderly and debilitated patients: 0.025-0.05 mg/kg
- Rectal administration in children for preoperative sedation: Rectal administration of the ampoule solution (0.35-0.45 mg/kg) 20-30 min before induction of general anesthesia
Interaction
Can enhance the central sedative effect of neuroleptics, tranquillizers, antidepressants, sleep-inducing drugs, analgesics, anaesthetics, antipsychotics, anxiolytics, antiepileptic drugs and sedative antihistamines
Contraindications
Must not be given to patients with severe respiratory insufficiency, severe hepatic insufficiency, myasthenia gravis, sleep apnea syndrome, and with known hypersensitivity to benzodiazepines or to any component of the product
Side Effects
- Drowsiness during daytime
- Confusion
- Fatigue
- Headache
- Muscle weakness
- Fluctuations in vital signs like respiratory depression, apnea, variations in blood pressure and pulse rate
Pregnancy & Lactation
Should be avoided during pregnancy unless there is no safer alternative, passes into breast milk and should not be administered to breast-feeding mothers
Precautions & Warnings
IV administration should be very slow
Overdose Effects
May lead to coma, areflexia, cardiorespiratory depression and apnea, can be controlled with benzodiazepine antagonist flumazenil
Therapeutic Class
- Benzodiazepine hypnotics
- Benzodiazepine sedatives
Storage Conditions
Protect from light and moisture, store in a cool and dry place, keep out of the reach of children