Defcort 6 mg/5 ml (Oral Suspension)
60 ml bottle: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Deflazacort |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Anaphylaxis
- Asthma
- Rheumatoid arthritis
- Juvenile chronic arthritis
- Systemic lupus erythematosus
- Dermatomyositis
- Mixed connective tissue disease
- Polyartritis nodosa
- Sarcoidosis
- Pemphigus
- Bullous pemphigoid
- Pyoderma gangrenosum
- Minimal change nephrotic syndrome
- Acute interstitial nephritis
- Rheumatic carditis
- Ulcerative colitis
- Crohn's disease
- Uveitis
- Optic neuritis
- Autoimmune haemolytic anaemia
- Idiopathic thrombocytopenic purpura
- Acute and lymphatic leukaemia
- Malignant lymphoma
- Multiple myeloma
- Immune suppression in transplantation
Pharmacology
Provides anti-inflammatory action by inhibiting Phospholipase A2 enzyme and decreases the release of certain chemicals important in the immune system.
Dosage & Administration
- Adults:
- For acute disorders: Up to 120 mg/day initially
- Maintenance doses usually within the range of 3-18 mg/day for most conditions
- Children:
- Juvenile chronic arthritis: Usual maintenance dose is between 0.25-1.0 mg/kg/day
- Nephrotic syndrome: Initial dose of usually 1.5 mg/kg/day followed by down titration according to clinical need
- Deflazacort withdrawal: In patients who have received more than physiological doses of systemic corticosteroids, withdrawal should not be abrupt
Interaction
Metabolized in the liver. Maintenance dose of Defcort may need to be increased if co-administered with liver enzyme inducers like rifampicin, carbamazepine, etc. Reduced maintenance dose possible with liver enzyme inhibitors
Contraindications
- Hypersensitivity to any of the ingredients
- Patients receiving live virus immunization
Side Effects
- GI disturbances
- Musculoskeletal issues
- Endocrine effects
- Neuropsychiatric effects
- Ophthalmic effects
- Fluid and electrolyte disturbances
- Increased susceptibility to infection
- Impaired healing
- Hypersensitivity reactions
- Skin atrophy
- Striae
- Telangiectasia
- Acne
- Myocardial rupture following recent MI
- Thromboembolism
Pregnancy & Lactation
- Pregnancy: May increase the risk of intrauterine growth retardation if used repeatedly during pregnancy
- Nursing Mother: Doses of up to 50 mg daily unlikely to cause systemic effects in the infant. Infants of mothers taking higher doses may have a degree of adrenal suppression
Precautions & Warnings
- Cardiac disease or congestive heart failure
- Hypertension
- Thromboembolic disorders
- Gastritis or oesophagitis
- Diverticulitis
- Ulcerative colitis
- Diabetes mellitus or family history
- Osteoporosis
- Myasthenia gravis
- Renal insufficiency
- Emotional instability or psychotic tendency
- Epilepsy
- Liver failure
- Hypothyroidism and cirrhosis
- Ocular herpes simplex
Use in Special Populations
- Hepatic Impairment: Blood levels may be increased, so careful monitoring and adjustment of the dose is necessary
- Renal Impairment: No special precautions necessary
- Elderly: Common adverse effects may have more serious consequences in old age
Therapeutic Class
Glucocorticoids
Storage Conditions
Store in a cool, dry place below 25°C, protected from light & moisture. Keep out of the reach of children