Alunib 90 mg (Tablet)
Unit Price: ৳ 1,200.00 (1 x 7: ৳ 8,400.00)
Strip Price: ৳ 8,400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Brigatinib |
| Company | Jenphar bangladesh ltd |
| Also available as |
Indications
- Treatment of ALK-positive metastatic Non-small cell lung cancer (NSCLC)
- Progression on or intolerance to Crizotinib
Pharmacology
- Inhibition of multiple kinases including ALK, ROS1, IGF-1R, and FLT-3
- Activity against EGFR deletion and point mutations
- Autophosphorylation and downstream signaling protein inhibition
- Pharmacokinetic properties (absorption, distribution, metabolism, elimination)
Dosage & Administration
- Initial dose of 90 mg orally once daily for the first 7 days
- If tolerated, increase to 180 mg orally once daily
- Administration until disease progression or unacceptable toxicity
- Recommendations for missed doses and vomiting after administration
Interaction
- Drugs that may increase plasma concentrations
- Drugs that may decrease plasma concentrations
- Drugs that may alter plasma concentrations of other drugs
Contraindications
- Known hypersensitivity to Brigatinib or its components
Side Effects
- Interstitial Lung Disease (ILD)/Pneumonitis
- Hypertension
- Bradycardia
- Visual Disturbance
- Creatine Phosphokinase (CPK) Elevation
- Pancreatic Enzyme Elevation
- Hyperglycemia
Pregnancy & Lactation
- No clinical data on use in pregnant women
- Advisory on potential risk to fetus during pregnancy
- Advice against breastfeeding during treatment and for 1 week following final dose
- Recommendations for reproductive potential in females and males
Precautions & Warnings
- Interstitial Lung Disease (ILD)/Pneumonitis
- Hypertension
- Bradycardia
- Visual Disturbance
- Creatine Phosphokinase (CPK) Elevation
- Pancreatic Enzyme Elevation
- Hyperglycemia
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Temperature below 30°C
- Protection from light and moisture
- Keep out of reach of children