Alunib 180 mg (Tablet)

Unit Price: ৳ 2,000.00 (1 x 30: ৳ 60,000.00)
Strip Price: ৳ 60,000.00

Medicine Details

Category Details
Generic Brigatinib
Company Jenphar bangladesh ltd
Also available as
Alunib 90 mg tablet Alunib 30 mg tablet

Title

  • Alunib

Categories

  • Medicine
  • Cancer Treatment
  • Oncology
  • Pharmacology

Description

  • Treatment for ALK-positive metastatic Non-small cell lung cancer (NSCLC)
  • Tyrosine kinase inhibitor with activity against multiple kinases
  • Recommended dosing regimen
  • Interactions with other drugs
  • Contraindications
  • Potential side effects
  • Usage during pregnancy and lactation
  • Precautions and warnings
  • Therapeutic class
  • Storage conditions

Indications

  • Treatment of ALK-positive metastatic NSCLC
  • Patients who have progressed on or are intolerant to Crizotinib

Pharmacology

  • In vitro activity against ALK, ROS1, IGF-1R, FLT-3, and EGFR
  • Inhibition of autophosphorylation of ALK and downstream signaling proteins
  • Distribution and elimination characteristics
  • Metabolism and excretion details

Dosage & Administration

  • Initial dose of 90 mg orally once daily for 7 days
  • Subsequent increase to 180 mg orally once daily if tolerated
  • Administration until disease progression or unacceptable toxicity
  • Guidelines for missed doses and vomiting after administration

Interaction

  • Drugs that may increase Alunib plasma concentrations
  • Drugs that may decrease Alunib plasma concentrations
  • Drugs that may alter plasma concentrations of other drugs

Contraindications

  • Hypersensitivity to Brigatinib or any other components

Side Effects

  • Interstitial Lung Disease (ILD)/Pneumonitis
  • Hypertension
  • Bradycardia
  • Visual Disturbance
  • Creatine Phosphokinase (CPK) Elevation
  • Pancreatic Enzyme Elevation
  • Hyperglycemia

Pregnancy & Lactation

  • Potential risk to fetus during pregnancy
  • Restrictions on breastfeeding
  • Use of contraception for females and males

Precautions & Warnings

  • Interstitial Lung Disease (ILD)/Pneumonitis
  • Hypertension
  • Bradycardia
  • Visual Disturbance
  • Creatine Phosphokinase (CPK) Elevation
  • Pancreatic Enzyme Elevation
  • Hyperglycemia
  • Genotoxicity and infertility in males

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Temperature below 30°C
  • Protection from light & moisture
  • Keep out of reach of children

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