Dentro 50 mg (Capsule)

Unit Price: ৳ 15.00 (3 x 6: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Dantrolene sodium
Company Healthcare pharmaceuticals ltd
Also available as

Indications

  • Controlling manifestations of clinical spasticity
  • Benefit for patients with upper motor neuronal disorders
  • Benefit for patients with spinal cord injury, stroke, cerebral palsy, or multiple sclerosis
  • Benefit for patients with presumably reversible spasticity
  • Reduction in painful and/or disabling spasticity
  • Reduction in intensity and/or degree of nursing care required
  • Benefit for patients with malignant hyperthermia
  • Prevention or attenuation of signs of malignant hyperthermia
  • Post-crisis follow-up for malignant hyperthermia
  • Significant reduction in spasticity manifestations
  • Rids the patient of annoying manifestations of spasticity

Pharmacology

  • Produces relaxation in skeletal muscle
  • Affects the contractile response of skeletal muscle
  • Interferes with the release of Ca++ from the sarcoplasmic reticulum
  • Dissociates excitation-contraction coupling

Dosage & Administration

  • Gradual titration schedule for adults
  • Gradual titration schedule for paediatric patients
  • Maximum accepted dosage is 400 mg per day for adults
  • Starting dose of 25 mg twice per day for adults
  • Dose escalation for paediatric patients
  • Administering oral Dentro preoperatively for malignant hyperthermia
  • Administering oral Dentro post-crisis for malignant hyperthermia

Interactions

  • Drowsiness may occur with Dentro therapy
  • Concomitant administration of CNS depressants may result in further drowsiness
  • Hepatotoxicity risk with concomitant estrogen therapy

Contraindications

  • Active hepatic disease such as hepatitis and cirrhosis

Side Effects

  • Drowsiness
  • Dizziness
  • Weakness
  • General malaise
  • Fatigue
  • Diarrhea
  • Transient side effects early in treatment

Pregnancy & Lactation

  • Pregnancy Category C
  • Use in pregnancy only if potential benefit justifies the potential risk to the fetus
  • Not to be used in nursing mothers

Precautions & Warnings

  • Potential for liver damage in long-term use
  • Therapy should be stopped if benefits are not evident within 45 days
  • Caution against driving or participating in hazardous occupations
  • Possible photosensitivity reaction
  • Monitoring of liver function during therapy
  • Potential for fatal and non-fatal liver disorders
  • Caution in females and patients over 35 years of age
  • Caution in patients with impaired pulmonary function
  • Caution in patients with severely impaired cardiac function
  • Caution in patients with a history of previous liver disease or dysfunction

Use in Special Populations

  • Long-term safety not established in pediatric patients under 5 years
  • Benefit-risk consideration of long-term use in pediatric patients

Therapeutic Class

  • Centrally acting Skeletal Muscle Relaxants

Storage Conditions

  • Store in a cool & dry place
  • Protect from light

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