Virodip 10 mg (Tablet)

Indications

• Treatment of chronic hepatitis B in adults with active viral replication
• Treatment for patients with persistent elevations in serum aminotransferases or histologically active disease

Pharmacology

• Adefovir dipivoxil is a diester prodrug of adefovir
• Adefovir inhibits HBV DNA polymerase
• Bioavailability of adefovir from a 10 mg single dose is 59%
• Adefovir is excreted through renal route

Dosage & Administration

• Recommended dose is 10 mg once daily
• Oral administration without regard to food

Interaction

• Pharmacokinetics unchanged when coadministered with lamivudine, trimethoprim/sulfamethoxazole, and acetaminophen
• Increased adefovir levels observed when co-administered with ibuprofen

Contraindications

• Contraindicated in patients with hypersensitivity to any components

Side Effects

• Common side effects include weakness, headache, stomach pain, and nausea
• Severe acute exacerbations of hepatitis reported upon discontinuation
• Chronic administration may result in nephrotoxicity

Pregnancy & Lactation

• Pregnancy Category C
• Use only if clearly needed after considering risks and benefits
• Not known whether adefovir is excreted in human milk

Precautions & Warnings

• Monitor hepatic function upon discontinuation
• Closely monitor renal function in patients at risk
• Possible dose adjustment for patients with renal dysfunction

Use in Special Populations

• Safety and effectiveness not established in pediatric patients
• Caution advised when prescribing to elderly patients
• Dose adjustment guidelines for patients with renal impairment

Overdose Effects

• Associated with gastrointestinal side effects
• Monitor for toxicity and apply standard supportive treatment

Therapeutic Class

• Hepatic viral infections (Hepatitis B)

Storage Conditions

• Store at cool and dry place
• Protect from light and moisture
• Keep out of reach of children

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