Virodip 10 mg (Tablet)
Unit Price: ৳ 25.00 (2 x 10: ৳ 500.00)
Strip Price: ৳ 250.00
Medicine Details
Category | Details |
---|---|
Generic | Adefovir dipivoxil |
Company | Unimed unihealth pharmaceuticals ltd |
Indications
- Treatment of chronic hepatitis B in adults with active viral replication
- Treatment for patients with persistent elevations in serum aminotransferases or histologically active disease
Pharmacology
- Adefovir dipivoxil is a diester prodrug of adefovir
- Adefovir inhibits HBV DNA polymerase
- Bioavailability of adefovir from a 10 mg single dose is 59%
- Adefovir is excreted through renal route
Dosage & Administration
- Recommended dose is 10 mg once daily
- Oral administration without regard to food
Interaction
- Pharmacokinetics unchanged when coadministered with lamivudine, trimethoprim/sulfamethoxazole, and acetaminophen
- Increased adefovir levels observed when co-administered with ibuprofen
Contraindications
- Contraindicated in patients with hypersensitivity to any components
Side Effects
- Common side effects include weakness, headache, stomach pain, and nausea
- Severe acute exacerbations of hepatitis reported upon discontinuation
- Chronic administration may result in nephrotoxicity
Pregnancy & Lactation
- Pregnancy Category C
- Use only if clearly needed after considering risks and benefits
- Not known whether adefovir is excreted in human milk
Precautions & Warnings
- Monitor hepatic function upon discontinuation
- Closely monitor renal function in patients at risk
- Possible dose adjustment for patients with renal dysfunction
Use in Special Populations
- Safety and effectiveness not established in pediatric patients
- Caution advised when prescribing to elderly patients
- Dose adjustment guidelines for patients with renal impairment
Overdose Effects
- Associated with gastrointestinal side effects
- Monitor for toxicity and apply standard supportive treatment
Therapeutic Class
- Hepatic viral infections (Hepatitis B)
Storage Conditions
- Store at cool and dry place
- Protect from light and moisture
- Keep out of reach of children