Derbicil 250 mg (Tablet)
Unit Price: ৳ 40.00 (1 x 10: ৳ 400.00)
Strip Price: ৳ 400.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Terbinafine hydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Title
- Derbicil Tablet
- Derbicil Granules
- Derbicil Cream
- Derbicil 1% Spray
Categories
- Antifungal Medication
- Prescription Medication
- Topical Antifungal
- Oral Antifungal
Indications
- Treatment of onychomycosis of toenail or fingernail due to dermatophytes
- Treatment of Tinea Capitis
- Treatment of fungal infections caused by Trichophyton, Microsporum, and Epidermophyton species
- Treatment of pityriasis (tinea) versicolor
- Treatment of yeast infections of the skin caused by Candida
- Relief of symptoms associated with tinea infections of the skin
Mode of Action
- Inhibition of Ergosterol biosynthesis in fungal cell membranes
- Fungicidal action against Tricophyton Mentagrophyte and Trichophyton Rubrum
Dosage and Administration
- Oral tablet for onychomycosis: 250mg once daily for 6-12 weeks
- Granules dosage based on body weight
- Topical cream application once or twice daily for specific durations
- 1% Spray application once or twice daily based on the indication
Interaction
- Inhibitor of CYP450 2D6 isozyme, may interact with various drug classes
Contraindications
- Hypersensitivity to terbinafine
Side Effects
- Gastrointestinal symptoms
- Liver test abnormalities
- Rashes
- Urticaria
- Pruritus
- Taste disturbances
- Idiosyncratic and symptomatic hepatic injury
- Serious skin reactions
- Severe neutropenia
- Thrombocytopenia
- Angioedema
- Allergic reactions
- Malaise
- Fatigue
- Vomiting
- Arthralgia
- Myalgia
- Hair loss
Pregnancy and Lactation
- Not recommended during pregnancy due to lack of controlled studies
- Excreted in breast milk, not recommended for nursing mothers
Precautions and Warnings
- Rare cases of liver failure reported
- Serious skin reaction risk
- Avoid contact with eyes for cream
- Assessment of pre-existing liver disease before treatment
- Hepatotoxicity may occur in patients with and without pre-existing liver disease
Use in Special Populations
- Safety and efficacy not established in pediatric patients
Overdose Effects
- Limited clinical experience, symptoms include nausea, vomiting, abdominal pain, dizziness
Therapeutic Class
- Antifungal preparations
Storage Conditions
- Store in cool, dry place below 30°C, protect from light