Salburen 100 mcg/puff (Inhaler)

Indications

• Treatment of bronchospasm in bronchial asthma
• Prevention of bronchospasm in bronchial asthma
• Treatment of reversible airway obstruction associated with bronchitis
• Treatment of reversible airway obstruction associated with emphysema
• Relief of acute dyspnea
• Prophylactic use before exertion
• Prophylactic use to prevent exercise-induced asthma

Pharmacology

• Selective β2-adrenoceptor agonist
• Acts on the β2-adrenoceptors of bronchial smooth muscle
• Fast onset of action within 5 minutes
• Short-acting bronchodilatation (4-6 hours)
• Anti-inflammatory effect on mast cells
• Inhibition of release of bronchoconstrictor mediators

Dosage

• Administer by oral inhalation only
• Shake well before each spray
• Maximum dose for adults: up to 8 puffs in 24 hours
• Maximum dose for children: half the adult dose
• Prophylactic dose for adults: 2 puffs 15 minutes prior to exercise or allergen exposure
• Chronic therapy dose for adults: up to 200 mcg (2 puffs) four times daily
• Chronic therapy dose for children: up to 200 mcg (2 puffs) four times daily

Administration

• Correct and regular use to prevent or lessen the severity of asthma attacks
• Inhaler usage steps according to National Asthma Guidelines
• Instructions for cleaning the Inhaler

Interaction

• Contraindicated with non-selective beta-blocking drugs such as propranolol
• Potentially serious hypokalaemia may result from β2-agonist therapy
• Caution advised in acute severe asthma with concomitant treatment with xanthine derivatives, steroids, diuretics, and hypoxia
• Recommended monitoring of serum potassium levels in certain situations

Contraindications

• History of hypersensitivity to salbutamol or any other components

Side Effects

• Tremors
• Anxiety
• Muscle cramps
• Headache
• Palpitation
• Compensatory small increase in heart rate
• Cardiac arrhythmias
• Tachycardia
• Mouth and throat irritation

Pregnancy & Lactation

• Pregnancy Category C
• Use during pregnancy only if potential benefit justifies potential risk to the fetus
• Caution during administration to nursing women

Precautions & Warnings

• Production of paradoxical bronchospasm
• Clinically significant cardiovascular effects in some patients
• Electrocardiograms (ECG) changes
• Immediate hypersensitivity reactions
• Caution in patients with convulsive disorders, hyperthyroidism, or diabetes mellitus
• Caution in patients unusually responsive to sympathomimetic amines
• Aggravation of preexisting diabetes mellitus and ketoacidosis reported

Use in Special Populations

• Safety and effectiveness established in children 4 years of age and older

Therapeutic Class

• Short-acting selective & β2-adrenoceptor stimulants

Storage Conditions

• Pressurized canister
• Do not puncture, break, or burn even when apparently empty
• Store below 30°C
• Do not freeze
• Keep away from eyes
• Keep away from children
• To be dispensed only on or by the prescription of a registered physician

Related Brands

• Proventa 100 mcg/puff (Inhaler) - opsonin-pharma-ltd