E-coxib 90 mg (Tablet)

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Etoricoxib
Company Drug international ltd
Also available as
E coxib 60 mg tablet E coxib 120 mg tablet

Indications

  • Symptomatic relief of Osteoarthritis (OA)
  • Symptomatic relief of Rheumatoid arthritis (RA)
  • Symptomatic relief of Ankylosing spondylitis
  • Symptomatic relief of acute gouty arthritis
  • Short-term treatment of moderate pain associated with dental surgery

Pharmacology

  • Potent, orally active cyclooxygenase-2 (COX-2) specific inhibitor
  • Decreases clinical signs and symptoms with decreased potential for GI toxicity and effects on platelet aggregation
  • Produces dose-dependent inhibition of COX-2 without inhibition of COX-1 at doses up to 150 mg daily

Dosage & Administration

  • Recommended dose for Osteoarthritis: 30 mg once daily, increased dose of 60 mg once daily in some patients
  • Recommended dose for Rheumatoid arthritis: 90 mg once daily
  • Recommended dose for Ankylosing spondylitis: 90 mg once daily
  • Recommended dose for Acute gouty arthritis: 120 mg once daily for 8 days
  • Recommended dose for Postoperative dental surgery pain: 90 mg once daily, max 3 days
  • Shortest duration possible and the lowest effective daily dose should be used

Interaction

  • E-coxib may increase prothrombin time when administered with oral anticoagulants
  • May reduce the effect of diuretics and other antihypertensive drugs when used with Diuretics, ACE inhibitors, and Angiotensin II Antagonists
  • Can be used concomitantly with low-dose acetylsalicylic acid for cardiovascular prophylaxis
  • Potential increase in nephrotoxic effects when coadministered with ciclosporin or tacrolimus
  • Decreases lithium renal excretion and therefore increases lithium plasma levels when used with Lithium

Contraindications

  • Hypersensitivity to the active substance or to any of the excipients
  • Active peptic ulceration or active GI bleeding
  • Patients with previous bronchospasm, acute rhinitis, nasal polyps, etc. after taking NSAIDs
  • Pregnancy and lactation
  • Severe hepatic dysfunction, estimated renal creatinine clearance <30 ml/min
  • Children and adolescents under 16 years of age
  • Inflammatory bowel disease, congestive heart failure, uncontrolled hypertension, established ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease

Side Effects

  • Palpitation
  • Fatigue
  • Influenza-like symptoms
  • Ecchymosis
  • Dry mouth
  • Taste disturbance
  • Atrial fibrillation
  • Transient ischemic attack
  • Chest pain
  • Anxiety
  • Myalgia
  • Arthralgia
  • Confusion
  • Hallucinations

Pregnancy & Lactation

  • Not recommended in women attempting to conceive
  • Excreted in the milk of lactating rats
  • Women who use Etoricoxib must not breastfeed

Precautions & Warnings

  • Caution advised with treatment of patients at risk of developing GI complication with NSAIDs
  • Patients with significant risk factors for cardiovascular events should be treated with caution
  • May cause a reduction in prostaglandin formation and impair renal function
  • Exercise caution in patients with a history of cardiac failure, left ventricular dysfunction, or hypertension
  • Monitor liver function, discontinue at the first appearance of hypersensitivity

Overdose Effects

Administration of single doses up to 500 mg and multiple doses up to 150 mg/day did not result in significant toxicity

Therapeutic Class

Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Store at a temperature below 30°C, protect from light & moisture, keep out of reach of children

Chemical Structure

  • Molecular Formula: C18H15ClN2O2S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-446-etoricoxib-chemical-structure-nEkDifKyFxQ9fjJEG7TQ.svg

Common Questions

  • What is E-coxib 90 mg Tablet?
  • What are the uses of E-coxib 90 mg Tablet?
  • Duration of effect of E-coxib 90 mg Tablet
  • Onset of action of E-coxib 90 mg Tablet
  • Pregnancy warnings of E-coxib 90 mg Tablet
  • Habit forming tendencies of E-coxib 90 mg Tablet
  • Breast-feeding warnings of E-coxib 90 mg Tablet
  • Safety with alcohol
  • Impact on kidney function
  • Impact on liver function
  • Quick Tips

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