E-coxib 60 mg (Tablet)
Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Etoricoxib |
| Company | Drug international ltd |
| Also available as |
Title and Categories
- E-coxib 60 mg Tablet
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Symptomatic Relief Indications
- Osteoarthritis (OA)
- Rheumatoid arthritis (RA)
- Ankylosing spondylitis
- Acute gouty arthritis
- Moderate pain associated with dental surgery
Pharmacology
- Potent cyclooxygenase-2 (COX-2) specific inhibitor
- Actions on COX-1 and COX-2 isoforms
- Mechanism for relieving pain, inflammation, and fever
Dosage Recommendations
- 30 mg daily for OA
- 90 mg daily for RA and Ankylosing spondylitis
- 120 mg daily for Acute gouty arthritis
- 90 mg daily for Postoperative dental surgery pain
- Incremental dosing for efficacy
Interactions
- Increase in prothrombin time with oral anticoagulants
- Reduced effect of diuretics and ACE inhibitors
- Concomitant use with low-dose acetylsalicylic acid
- Potential nephrotoxic effect with ciclosporin and tacrolimus
- Increased lithium plasma levels with lithium
Contraindications
- Hypersensitivity reactions
- Active peptic ulceration or Gl bleeding
- Allergic reactions to NSAIDs or COX-2 inhibitors
- Pregnancy, lactation
- Severe hepatic dysfunction, renal impairment
- Children under 16 years, inflammatory bowel disease
- Congestive heart failure, uncontrolled hypertension
- Ischaemic heart disease, peripheral arterial disease
Side Effects
- Palpitation, fatigue, influenza-like symptoms
- Dry mouth, taste disturbance, mouth ulcer
- Appetite and weight change, atrial fibrillation
- Chest pain, flushing, cough, dyspnoea
- Anxiety, mental acuity impairment, paraesthesia
- Electrolyte disturbance, myalgia, arthralgia
- Confusion, hallucinations (rare)
Pregnancy & Lactation
- Not recommended during conception
- Excreted in rat milk, avoid breastfeeding
Precautions & Warnings
- Caution in patients at risk of GI complications with NSAIDs
- Consideration for cardiovascular risk factors
- Monitoring renal function, especially in high-risk patients
- Exercise caution in cardiac and edema conditions
- Monitor liver function, discontinue on hepatic signs
- Discontinue immediately on signs of hypersensitivity
- Potential interaction with warfarin and anticoagulants
Overdose Effects
- No significant toxicity at 500 mg single dose
- Supportive measures recommended in case of overdose
Chemical Structure
- Molecular Formula: C18H15ClN2O2S
- Chemical Structure Image
Storage Conditions
- Store below 30°C, protect from light and moisture
- Keep out of reach of children
Duration of Effect
20-24 hours
Onset of Action
1-2 hours, faster without food
Safety Precautions
- Caution with alcohol consumption
- Avoid driving due to potential alertness effects
Effect on Kidney & Liver Function
- Caution in kidney disease, adjust dose if needed
- Strictly not recommended in severe kidney/liver disease
Quick Tips
- Relieves pain and inflammation
- May cause fewer stomach problems compared to other NSAIDs
- Causes dizziness and fatigue, avoid tasks requiring concentration
- Avoid alcohol consumption for reduced drowsiness
- Monitor blood pressure regularly, especially in initial weeks
- Inform doctor about medical history before treatment
- Regularly monitor liver function during long-term use
- Avoid if pregnant, planning for conception, or breastfeeding