Prioxim 400 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Cefixime trihydrate |
| Company | Dbl pharmaceuticals ltd |
| Also available as |
Title
- Prioxim 400 mg Tablet
Categories
- Medicine
- Antibiotics
- Cephalosporin
Description
Prioxim 400 mg Tablet is an orally active cephalosporin antibiotic with bactericidal activity against a wide variety of Gram-positive and Gram-negative organisms, indicated for upper respiratory tract infections, lower respiratory tract infections, urinary tract infections, and more.
Brand
Prioxim
Dosage form
- Tablet
Dosage strength
400 mg
Pharmacology
Cefixime is a third generation semisynthetic cephalosporin antibiotic for oral administration, bactericidal against a broad spectrum of gram positive and gram negative bacteria by interfering in the synthesis of bacterial cell wall.
Mode of action
Interferes with bacterial cell wall synthesis
Absorption rate
Approximately 40% to 50%
Recommended course
7 to 14 days
Recommended dosage
- Adults: 200-400 mg daily
- Adults note: Single dose or in two divided doses
- Elderly: Same dose as recommended for adults
- Children over 10: 200-400 mg daily
- Children under 10: 8 mg/kg/day
Recommended dosage by age
- 6 months to 1 year: 3.75 ml daily
- 1 to 4 years: 5 ml daily
- 5 to 10 years: 10 ml daily
- Typhoid children: 5 mg/kg body weight twice daily for 10-14 days
Renal impairment dosage
In patients with creatinine clearances of less than 20 ml/min, a dose of 200 mg once daily should not be exceeded
Interaction
- Increases in prothrombin times have been noted with anticoagulant therapy
Contraindications
- Known hypersensitivity to cephalosporin antibiotics
Side effects
- Gastrointestinal disturbances:
- Diarrhoea
- Nausea
- Abdominal pain
- Dyspepsia
- Vomiting
- Flatulence
- Central nervous system:
- Headache
- Dizziness
- Hypersensitivity reactions:
- Rash
- Pruritis
- Urticaria
- Drug fever
- Arthralgia
- Hematological and clinical chemistry:
- Thrombocytopenia
- Leukopenia
- Eosinophilia
- Miscellaneous:
- Genital pruritis
- Vaginitis
Pregnancy and lactation
Use during pregnancy only if clearly needed. Caution should be exercised when administered to a nursing woman
Precautions and warnings
- Allergies: Given with caution to patients who have shown hypersensitivity to other drugs
- Penicillin sensitive patients: Given with caution due to partial cross-allergenicity between penicillins and cephalosporins
- Renal function: Given with caution in patients with markedly impaired renal function
- Antibiotic associated diarrhoea: Alters the normal flora of the colon and may permit overgrowth of clostridia
Overdose effects
Gastric Lavage may be indicated; otherwise, no specific antidote exists. Adverse reactions in small numbers of healthy adult volunteers receiving single doses up to 2 g of Prioxim did not differ from the profile seen in patients treated at the recommended doses
Therapeutic class
Third generation Cephalosporins
Storage conditions
Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children
Chemical structure
- Molecular formula: C16H15N5O7S2
- Chemical structure image: https://medex.com.bd/storage/res/g-res-217-cefixime-trihydrate-chemical-structure-3Mg9h2a2PuSZaJk4Uj0Z.svg
Commonly asked questions
- Common uses:
- Urinary tract infection
- Tonsillitis
- Pharyngitis
- Bronchitis
- Fungal and Gonococcal infections
- Side effects:
- Diarrhea
- Abdominal pain
- Swelling of the face, lips, eyelids, tongue, hands, and feet
- Dizziness
- Storage and disposal instructions: Keep in a cool dry place and in its original pack. Keep unreachable to children and pets. Proper disposal of the expired and unused medications is important to avoid health problems
- Special dietary instructions: Continue normal diet unless advised otherwise by a doctor
- Interaction with contraception: No evidence suggested the effect on contraceptive medications
- Acetaminophen interaction: No clinically proven interactions with Acetaminophen (Paracetamol)
- Time to work: Starts working soon after ingestion, may take a few days to relieve symptoms completely