Delpark 5 mg/5 ml (Syrup)
50 ml bottle: ৳ 125.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct in the treatment of all forms of parkinsonism
- Adjuvant therapy with levodopa
- Control of extrapyramidal disorders caused by CNS drugs
Description
- Exerts direct inhibitory effect upon the parasympathetic nervous system
- Relaxing effect on smooth musculature
- Direct and indirect effect on muscle tissue
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Higher affinity to M1 subtype
- Higher affinity for central muscarinic receptors in cerebral cortex
- Lower affinity for peripherally located receptors
- Potential modification of nicotinic acetylcholine receptor neurotransmission
Dosage & Administration
- Individualized dosage
- Low initial dose for patients over 60 years
- Gradual dose increase
- Adjustment of dosage based on patient reaction
- Specific dosing recommendations for different forms of parkinsonism
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with concurrent use of alcohol or other CNS depressants
- Intensification of anticholinergic effects with MAO inhibitors and tricyclic antidepressants
- Increased risk for tardive dyskinesia with concomitant administration of anticholinergics and neuroleptics
Contraindications
- Hypersensitivity to trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Delusions
- Hallucinations
- Memory impairment
- Constipation
- Drowsiness
- Tachycardia
- Dilation of the pupil
- Increased intraocular pressure
- Choreiform movements
Pregnancy & Lactation
- Limited data on use during pregnancy
- Caution advised during nursing
Precautions & Warnings
- Gonioscope evaluation prior to therapy
- Close monitoring of intraocular pressures
- Caution in hot weather
- Anhidrosis in hot environment
Overdose Effects
- Central symptoms of atropine intoxication
- Peripheral signs of parasympathetic blockade
- Neuropsychiatric signs
Therapeutic Class
Antiparkinson drugs
Storage Conditions
Store at temperature not exceeding 30°C