Goodmet 500 mg (Tablet)

Unit Price: ৳ 3.00 (6 x 10: ৳ 180.00)
Strip Price: ৳ 30.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Goodman pharmaceuticals ltd
Also available as
Goodmet 850 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Suitable for overweight patients
  • Can be used as monotherapy
  • Can be used in combination with other oral antidiabetic agents
  • Can be used in combination with insulin
  • Shows reduction of diabetic complications
  • Suitable for adults
  • Suitable for children from 10 years of age and adolescents

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action from sulfonylureas
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity

Dosage & Administration

  • Available as immediate release tablet
  • Available as extended release tablet
  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses should not be exceeded
  • Dosage adjustments for different patient groups (adults, children)
  • Specific dosage for renal impaired patients

Interaction

  • Potential interaction with Furosemide
  • Enhancement of absorption by Nifedipine
  • No effect on Cimetidine pharmacokinetics
  • Possible interactions with cationic drugs
  • Certain drugs tend to produce hyperglycemia

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions with potential to alter renal function
  • Acute or chronic diseases causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy in patients with vitamin B12 deficiency
  • Taste disturbance
  • Gastrointestinal disorders (nausea, vomiting, diarrhea)
  • Liver function test abnormalities or hepatitis

Pregnancy & Lactation

  • Increased risk of congenital abnormalities and perinatal mortality
  • Breastfeeding not recommended during treatment

Precautions & Warnings

  • Excreted by the kidney
  • Potential for lactic acidosis
  • Lowering of vitamin B12 levels
  • Increased risk of hypoglycemia
  • Regular monitoring of renal function advised
  • Therapy should be stopped before certain clinical investigations
  • Annual estimation of Vitamin B-12 levels recommended

Use in Special Populations

  • Adjusted dosage for elderly subjects based on renal function
  • No effect on growth and puberty detected in controlled clinical studies
  • Regular assessment of renal function necessary
  • Particular caution recommended for children aged between 10 and 12 years

Overdose Effects

  • Lactic acidosis is a medical emergency
  • Treatment in hospital required
  • Hemodialysis is the most effective method for removal

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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