Goodmet 500 mg (Tablet)
Unit Price: ৳ 3.00 (6 x 10: ৳ 180.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Goodman pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Suitable for overweight patients
- Can be used as monotherapy
- Can be used in combination with other oral antidiabetic agents
- Can be used in combination with insulin
- Shows reduction of diabetic complications
- Suitable for adults
- Suitable for children from 10 years of age and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- Does not produce hypoglycemia
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Available as immediate release tablet
- Available as extended release tablet
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses should not be exceeded
- Dosage adjustments for different patient groups (adults, children)
- Specific dosage for renal impaired patients
Interaction
- Potential interaction with Furosemide
- Enhancement of absorption by Nifedipine
- No effect on Cimetidine pharmacokinetics
- Possible interactions with cationic drugs
- Certain drugs tend to produce hyperglycemia
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions with potential to alter renal function
- Acute or chronic diseases causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Gastrointestinal disorders (nausea, vomiting, diarrhea)
- Liver function test abnormalities or hepatitis
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality
- Breastfeeding not recommended during treatment
Precautions & Warnings
- Excreted by the kidney
- Potential for lactic acidosis
- Lowering of vitamin B12 levels
- Increased risk of hypoglycemia
- Regular monitoring of renal function advised
- Therapy should be stopped before certain clinical investigations
- Annual estimation of Vitamin B-12 levels recommended
Use in Special Populations
- Adjusted dosage for elderly subjects based on renal function
- No effect on growth and puberty detected in controlled clinical studies
- Regular assessment of renal function necessary
- Particular caution recommended for children aged between 10 and 12 years
Overdose Effects
- Lactic acidosis is a medical emergency
- Treatment in hospital required
- Hemodialysis is the most effective method for removal
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children