Litam 250 mg (Tablet)

Unit Price: ৳ 15.00 (2 x 10: ৳ 300.00)
Strip Price: ৳ 150.00

Medicine Details

Category Details
Generic Levetiracetam
Company Goodman pharmaceuticals ltd
Also available as
Litam 500 mg tablet

Indications

  • treatment of partial-onset seizures
  • monotherapy for adults and adolescents
  • adjunctive therapy for adults, adolescents, children, and infants
  • treatment of myoclonic seizures
  • treatment of primary generalized tonic-clonic seizures

Description

  • unknown precise mechanism of antiepileptic effect
  • minimal activity in submaximal stimulation
  • protection against secondarily generalized activity
  • inhibition of burst firing without affecting normal neuronal excitability

Dosage

  • recommended starting dose of 250 mg twice daily for adults and adolescents from 16 years of age
  • initial therapeutic dose of 500 mg twice daily
  • maximum dose of 1500 mg twice daily for adults and adolescents
  • adapted oral solution for infants and children under the age of 6 years

Administration

  • tablet form for oral administration
  • to be taken with sufficient liquid
  • administered in two equally divided doses

Interaction

  • no influence on serum concentrations of existing antiepileptic medicinal products
  • interaction with probenecid and methotrexate
  • reports of decreased efficacy when concomitantly administered with macrogol
  • no alteration in absorption with food
  • slightly reduced absorption rate by food

Contraindications

  • hypersensitivity to the active substance or other pyrrolidone derivatives or excipients

Side Effects

  • common adverse reactions in adult and pediatric patients
  • incidence ≥ 5% more than placebo
  • includes somnolence, asthenia, infection, dizziness, fatigue, aggression, nasal congestion, decreased appetite, irritability

Pregnancy & Lactation

  • not recommended during pregnancy and lactation
  • excreted in human breast milk
  • impact on fertility is unknown

Precautions & Warnings

  • dose adjustment for renal impairment
  • rare cases of decreased blood cell counts
  • association with acute kidney injury
  • monitoring for signs of depression and suicidal ideation
  • tablet formulation not adapted for use in children under 6 years
  • impact on growth and puberty needs further study

Use in Special Populations

  • dose adjustment in elderly and patients with compromised renal or hepatic function

Overdose Effects

  • observed effects include somnolence, agitation, aggression, depressed level of consciousness, respiratory depression, and coma
  • no specific antidote
  • treatment of overdose is symptomatic
  • may include haemodialysis

Therapeutic Class

  • adjunct anti-epileptic drugs

Storage Conditions

  • store at a cool temperature not exceeding 25°C
  • store in a dry place
  • protect from light

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