Motiwin 10 mg (Tablet)

Unit Price: ৳ 3.00 (10 x 10: ৳ 300.00)
Strip Price: ৳ 30.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Goodman pharmaceuticals ltd
Also available as
Motiwin 5 mg suspension

Title

Motiwin 10 mg Tablet

Categories

  • Medicine
  • Health
  • Pharmacy

Description

Motiwin 10 mg Tablet is a dopamine antagonist medication used to treat dyspeptic symptom complex, acute nausea and vomiting, Parkinson's disease, and to speed barium transit in follow-through radiological studies.

Dosage

  • Adults:
    • 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily
  • Children:
    • 2-4 ml suspension/10 kg body weight, every 6-8 hours daily

Administration

  • Route: Oral
  • Timing: 15-30 minutes before meals and if necessary before retiring

Pharmacology

  • Action: Blocks dopamine receptors in the Chemoreceptor Trigger Zone and stomach
  • Effects:
    • Restores normal motility and tone of the upper gastrointestinal tract
    • Facilitates gastric emptying
    • Enhances antral and duodenal peristalsis
    • Regulates contraction of the pylorus
    • Increases esophageal peristalsis and lower esophageal sphincter pressure

Indications

  • DyspepticSymptoms:
    • Epigastric fullness
    • Upper abdominal pain
    • Nausea and vomiting
    • Heartburn
    • Non-ulcer dyspepsia
  • AcuteNauseaVomiting:
    • Functional, organic, dietetic origin
    • Induced by radiotherapy or drug therapy
  • ParkinsonsDisease:
    • Dopamine-agonist induced nausea and vomiting
  • RadiologicalStudies:
    • Speeding barium transit

DrugInteraction

  • AntagonisticDrugs:
    • Anticholinergic drugs
  • BioavailabilityLoweringDrugs:
    • Antacids
    • Antisecretory drugs
  • CYP3A4Inhibitors:
    • Azole antifungals
    • Macrolide antibiotics
    • HIV protease inhibitors
    • Nefazodone

Contraindications

  • Hypersensitivity to the drug
  • Neonates
  • Gastrointestinal hemorrhage
  • Mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor

SideEffects

  • Common:
    • Transient intestinal cramps
  • Rare:
    • Extrapyramidal phenomena in young children
    • Increase in plasma prolactin level
    • Allergic reactions such as rash and urticaria

PregnancyAndLactation

  • UseInPregnancy: Caution during first trimester
  • Breastfeeding: Not recommended unless benefits outweigh risks

PrecautionsAndWarnings

  • Children: Increased risk of extrapyramidal reactions
  • LiverImpairment: Caution in patients with hepatic impairment

SpecialPopulations

  • Infants: Caution due to incomplete blood-brain barrier
  • LiverDisorders: Caution due to high liver metabolism
  • KidneyDisorders: Caution in severe renal insufficiency

OverdoseEffects

  • Drowsiness
  • Disorientation
  • Extrapyramidal reactions

TherapeuticClass

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

StorageConditions

  • Temperature: Below 30°C
  • Protection: From light and moisture

ChemicalStructure

  • MolecularFormula: C22H24ClN5O2

CommonQuestions

  • Usage: Relieves nausea, vomiting, and indigestion
  • Tips:
    • Take before meals as per doctor's prescription
    • May cause dizziness and sleepiness
    • Avoid consuming alcohol while on medication
    • Inform your doctor about persistent symptoms
    • Do not take for longer than 7 days without consulting your doctor

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