Olmefast 20 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Olmesartan medoxomil |
| Company | Goodman pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of hypertension
- Can be used alone or in combination with other antihypertensive agents
Pharmacology
- Angiotensin II formation from angiotensin I
- Vasoconstrictor effects of olmesartan
- Selective blocking of AT 1 receptor in vascular smooth muscle
- AT 1 receptor affinity over 12500-fold greater than AT 2 receptor
- Does not inhibit ACE (kininase II) or affect bradykinin response
- Inhibition of angiotensin II receptor negative regulatory feedback on renin secretion
Dosage & Administration
- Usual recommended starting dose of 20 mg once daily
- 40 mg for further reduction in blood pressure after 2 weeks
- No advantage of twice-daily dosing
- No initial dosage adjustment recommended for elderly patients or those with moderate to marked renal or hepatic impairment
- Consideration for use of lower starting dose in patients with possible depletion of intravascular volume
- May be administered with or without food
Interaction
- No significant drug interactions with digoxin or warfarin reported
- Bioavailability not significantly altered by co-administration of antacids
- Not metabolized by cytochrome P450 system
- No effect on P450 enzymes
- Potential interaction with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) including selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) leading to deterioration of renal function
- Antihypertensive effect may be attenuated by NSAIDs including selective COX-2 inhibitors
Contraindications
- Hypersensitivity to any component of the product
Side Effects
- Well-tolerated with adverse reaction incidence similar to placebo
- Dizziness as the only adverse reaction occurring in more than 1% of patients
- Other adverse reactions occurring at an incidence of more than 1%
- No dose-related overall frequency of adverse reactions
Pregnancy & Lactation
- Discontinue use when pregnancy is detected
- Potential excretion in human milk with unknown effects on nursing infant
Precautions & Warnings
- Potential changes in renal function
- Association with oliguria and/or progressive azotemia in susceptible individuals
- Similar effects to those observed with angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists
Overdose Effects
- No experience of overdose with Olmefast
- Likely effects include hypotension and tachycardia
- Bradycardia possible with parasympathetic (vagal) stimulation
- Gastric lavage or induction of emesis may be considered for recent intakes
- Clinically significant hypotension requires active cardiovascular system support
Therapeutic Class
- Angiotensin-ll receptor blocker
Storage Conditions
- Store in cool & dry place below 30°C
- Protect from light & moisture
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C29H30N6O6
- Chemical Structure: (image URL)
Common Questions about Olmefast 20 mg Tablet
- Uses of Olmefast 20 mg Tablet
- Time taken to reach peak effect
- Frequency of use
- Administration instructions
- Storage and disposal instructions
- Quick Tips for usage
Quick Tips
- Take at the same time every day
- Be cautious of dizziness in the initial days
- Regular tests for monitoring urea, creatinine, and potassium levels
- Avoid anti-inflammatory medicines without consulting doctor
- Potential increase in blood potassium level
- Not suitable during pregnancy or breastfeeding
- Avoid sudden discontinuation without consulting doctor