Preneu 50 mg (Tablet)

Indications

• Neuropathic pain associated with diabetic peripheral neuropathy (DPN)
• Postherpetic neuralgia (PHN)
• Adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older
• Fibromyalgia
• Neuropathic pain associated with spinal cord injury

Pharmacology

• Structural derivative of inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
• Binds with high affinity to the alpha2-delta site
• Anti-nociceptive and antiseizure effects

Dosage

• Maximum recommended dose of Pregabalin is 100 mg three times a day for adults with diabetic peripheral neuropathy
• Recommended dose of Pregabalin is 75-150 mg two times a day for adults with postherpetic neuralgia
• Recommended dose of Pregabalin is 300-450 mg/day for management of fibromyalgia in adults
• Recommended dose range of Pregabalin is 150-600 mg/day for adults with spinal cord injury

Administration

• Oral route of administration
• Can be taken with or without food
• Pregabalin CR tablet should be administered after an evening meal

Interaction

• Unlikely to be involved in significant pharmacokinetic drug interactions

Contraindications

• Contraindicated in patients with known hypersensitivity to Pregabalin or any of its components

Side Effects

• Common side effects in adults include dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, and thinking abnormalities
• In pediatric patients, common side effects for the treatment of partial onset seizures are increased weight and increased appetite

Pregnancy & Lactation

• No adequate and well-controlled studies in pregnant women
• Small amount of pregabalin detected in the milk of lactating women
• Breastfeeding is not recommended during treatment with pregabalin due to potential risk of tumorigenicity

Precautions & Warnings

• Angioedema can occur and may be associated with life-threatening respiratory compromise
• Discontinue immediately in cases of hypersensitivity reactions
• Increase risk of suicidal thoughts or behavior
• May cause dizziness, somnolence, and impair patient's ability to drive or operate machinery

Use in Special Populations

• Safety and effectiveness in pediatric patients have not been established for various indications

Overdose Effects

• Signs and symptoms include reduced consciousness, depression/anxiety, confusional state, agitation, restlessness, seizures, and heart block
• No specific antidote

Therapeutic Class

• Adjunct anti-epileptic drugs
• Primary anti-epileptic drugs

Storage Conditions

• Keep in a cool & dry place (below 30°C), protected from light & moisture
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C8H17NO2

Common Questions about Preneu 50 mg Tablet

• First-line of treatment for neurotic pain, shingles, seizures, and fibromyalgia
• Usage frequency should be as prescribed by the doctor
• Should be taken after food in a prescribed dosage
• Should be kept in a cool dry place and in its original packaging
• Works in different ways for different diseases
• Duration of usage depends on the condition and should be consulted with the doctor
• Should not be stopped suddenly without consulting the doctor
• May cause weight gain due to increased hunger

Related Brands

• GABA-P 50 mg (Capsule) - renata-limited
• GABA-P 75 mg (Capsule) - renata-limited
• Gabarol 25 mg (Capsule) - aci-limited
• Gabarol 50 mg (Capsule) - aci-limited
• Gabarol 75 mg (Capsule) - aci-limited