Ursohil 300 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ursodeoxycholic acid |
| Company | Goodman pharmaceuticals ltd |
| Also available as |
Indications
- Cholestasis (Jaundice)
- Viral Hepatitis
- Alcoholic Fatty Liver
- Primary Billiary Cirrhosis (PBC)
- Primary Sclerosing Cholangitis (PSC)
- Dissolution of Gallstones
- Non-Alcoholic Steato Hepatitis (NASH)
Description
Ursohil is used to reduce the cholesterol saturation of bile and to promote the dissolution of gallstones. The cholesterol saturation of bile is reduced by Ursohil, allowing gradual solubilization of cholesterol gallstones. Cholesterol of secretion into bile is reduced and bile acid secretion rate is increased during Ursohil treatment without a reduction in phospholipids.
Pharmacology
- Decrease in secretion of cholesterol in bile
- Reduction of cholesterol absorption
- Suppression of liver cholesterol synthesis
- Promotion of formation of liquid cholesterol crystal complexes
- Improvement of cholestatic liver diseases
Dosage & Administration
- Dissolution of Gall stones: 8-12 mg/kg/day either as single night time dose or in divided doses
- Primary Billiary Cirrhosis: 10-15 mg/kg/day in 2-4 divided doses
- Acute Viral Hepatitis: 600 mg/day
- Alcoholic Fatty Liver: 300 mg/day
- Primary Sclerosing Cholangitis: 25-30 mg/kg/day
- Non-Alcoholic Steato Hepatitis: 13-15 mg/kg/day
Interaction
Should not be used with oestrogenic hormones or bile-acid binding drugs including antacids, charcoal and cholestyramine.
Contraindications
- Non-functioning gall-bladder
- Calcified and pigmented gallstones
- Inflammatory bowel disease
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Gallstone opacilication
- Pruritus
Pregnancy & Lactation
Pregnancy category B. No evidence of harm has been reported in pregnancy. It has been effectively used for the treatment of cholestasis of pregnancy during the last trimester without any side effects. No documented problems regarding breastfeeding.
Precautions & Warnings
Should be used cautiously in those with liver disease
Therapeutic Class
Anti-gallstones drugs: Bile Acids
Storage Conditions
Store below 25°C. Protected from light and moisture. Keep out of the reach of children