Zerolip 10 mg (Tablet)
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Atorvastatin calcium |
| Company | Goodman pharmaceuticals ltd |
| Also available as |
Indications
- Reduces total cholesterol in patients with familial hypercholesterolaemia
- Reduces triglycerides levels in patients with mixed dyslipidemia
- Treats hypertriglyceridaemia and dysbetalipoproteinaemia
- Reduces cardiac ischaemic events in patients with coronary artery disease
- Reduces cholesterol concentrations in patients with diabetes mellitus or renal transplantation
Pharmacology
- Selective inhibitor of HMG-CoA reductase
- Lowers plasma cholesterol and lipoprotein levels
- Increases hepatic LDL receptors for enhanced uptake and catabolism of LDL
- Rapidly absorbed after oral administration
- Extensively metabolized to active derivatives
- Eliminated primarily in bile
- Half-life of inhibitory activity for HMG-CoA reductase
Dosage & Administration
- Initial dose is usually 10 mg once daily for adults
- Maximum dosage can be increased at intervals of at least 4 weeks
- Dosage range is 10 to 80 mg once daily
Interaction
- Increased risk of myopathy with concurrent administration of certain drugs
- Plasma concentrations affected by coadministration with antacid, colestipol, digoxin, erythromycin, oral contraceptives, or warfarin
Contraindications
- Hypersensitivity to any component of the medication
- Active liver disease or unexplained persistent elevations of serum transaminases
- History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors
Side Effects
- Constipation
- Flatulence
- Dyspepsia
- Abdominal pain
- Infection
- Headache
- Back pain
- Rash
- Asthenia
- Arthralgia
- Myalgia
Pregnancy & Lactation
- Contraindicated during pregnancy
- Not known whether excreted in human milk
- Potential reduction of fetal levels of mevalonate
Precautions & Warnings
- Liver function tests should be performed before initiation of treatment
- Use with caution in patients with substantial alcohol consumption or history of liver disease
- Discontinue therapy if markedly elevated CPK levels occur or myopathy is diagnosed or suspected
Use in Special Populations
- Plasma concentrations are higher in healthy elderly subjects
- No clinically significant difference in LDL-C reduction between men and women
- Renal disease has no influence on plasma concentrations
- Hemodialysis not expected to significantly enhance drug clearance
- Markedly increased plasma concentrations in patients with chronic alcoholic liver disease
Overdose Effects
- Specific treatment unavailable
- Symptomatic and supportive measures should be instituted
- Liver function tests and serum CK levels should be monitored
Therapeutic Class
- Other Anti-anginal & Anti-ischaemic drugs
- Statins
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C33H35FN2O5
Common Questions about Zerolip 10 mg Tablet
- Used to avoid heart attacks and treat conditions like Mixed Dyslipidemia and Hypertriglyceridemia
- Should be taken by mouth once daily, at the same time each day
- Used for the treatment of diseases like heart attacks and Primary Hypercholesterolemia
- Possible side-effects include cough, muscle pain, breathing difficulty, and running nose
- Should be stored at room temperature, away from heat and direct light