Zerolip 20 mg (Tablet)

Unit Price: ৳ 16.00 (2 x 10: ৳ 320.00)
Strip Price: ৳ 160.00

Medicine Details

Category Details
Generic Atorvastatin calcium
Company Goodman pharmaceuticals ltd
Also available as
Zerolip 10 mg tablet

Title

  • Zerolip 20 mg Tablet

Therapeutic Class

  • Other Anti-anginal & Anti-ischaemic drugs
  • Statins

Dosage Administration

  • Adults: Usually 10 mg once daily; max. 80 mg once daily
  • Child (10-18 years): Initially 10 mg once daily, max. 20 mg once daily

Indications

  • Reduce total cholesterol and LDL cholesterol in patients with heterozygous and homozygous familial hypercholesterolaemia
  • Reduce elevated cholesterol and triglycerides in patient with mixed dyslipidemia (Fredrickson Type Ia and Ib)
  • Treatment of patients with elevated serum triglyceride levels in hypertriglyceridaemia (Fredrickson Type IV)
  • Treatment of patients with dysbetalipoproteinaemia (Fredrickson Type III)
  • Reduce cardiac ischaemic events in patients with asymptomatic or mild to moderate symptomatic coronary artery disease with elevated LDL-cholesterol level
  • Reduce total and LDL-cholesterol concentrations patients with hypercholesterolemia associated with or exacerbated by diabetes mellitus or renal transplantation

Pharmacology

  • Mode of Action: Selective inhibitor of HMG-CoA reductase
  • Absorption: Rapidly absorbed after oral administration
  • Distribution: Mean volume of distribution approximately 381 liters; 98% bound to plasma proteins
  • Metabolism: Extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products; metabolized by cytochrome P450 3A4
  • Excretion: Eliminated primarily in bile following hepatic and/or extra-hepatic metabolism; mean plasma elimination half-life approximately 14 hours

Interaction

  • Increased risk of myopathy with concurrent administration of cyclosporine, fibric acid derivatives, niacin, erythromycin, azole antifungals
  • Decreased plasma concentrations of atorvastatin when coadministered with antacid suspension or colestipol
  • Increased plasma concentrations of atorvastatin with coadministration of digoxin, erythromycin, oral contraceptives

Contraindications

  • Hypersensitivity to any component of this medication
  • Active liver disease or unexplained persistent elevations of serum transaminases
  • History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors

Side Effects

  • Constipation
  • Flatulence
  • Dyspepsia
  • Abdominal pain
  • Infection
  • Headache
  • Back pain
  • Rash
  • Asthenia
  • Arthralgia
  • Myalgia

Pregnancy Lactation

  • Pregnancy: Contraindicated; safety not established; may reduce fetal levels of mevalonate
  • Lactation: Not known if excreted in human milk; contraindicated during breastfeeding

Precautions Warnings

  • Liver function tests should be performed before initiation of treatment and periodically thereafter
  • Use with caution in patients who consume substantial quantities of alcohol or have a history of liver disease
  • Discontinue therapy if markedly elevated CPK levels occur or myopathy is diagnosed or suspected

Use in Special Populations

  • Geriatric: Plasma concentrations are higher in healthy elderly subjects
  • Pediatric: Pharmacokinetic data not available
  • Gender: No clinically significant difference in LDL-C reduction between men and women
  • Renal Insufficiency: No influence on plasma concentrations or LDL-C reduction
  • Hemodialysis: Not expected to significantly enhance clearance of Zerolip
  • Hepatic Insufficiency: Plasma concentrations are markedly increased in patients with chronic alcoholic liver disease

Overdose Effects

Specific treatment is not available for atorvastatin overdose; treat symptomatically and institute supportive measures

Storage Conditions

Keep in a dry place away from light and heat; keep out of the reach of children

Compound Summary

  • Molecular Formula: C33H35FN2O5
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-92-atorvastatin-calcium-chemical-structure-vKDE8RIA4syu8MLTgdLW.svg

Common Questions

  • What is Zerolip 20 mg Tablet?
  • How should I take Zerolip 20 mg Tablet?
  • What are the uses of Zerolip 20 mg Tablet?
  • What are the Side Effects of Zerolip 20 mg Tablet?
  • What are the instructions for storage and disposal of Zerolip 20 mg Tablet?
  • Is Zerolip 20 mg Tablet used for lowering cholesterol?
  • Will taking Zerolip 20 mg Tablet increase my risk of diabetes?
  • For how long do I need to take Zerolip 20 mg Tablet? Is it safe for long-term use?
  • Does Zerolip 20 mg Tablet cause weight loss?
  • Can I stop taking Zerolip 20 mg Tablet?
  • Does Zerolip 20 mg Tablet cause memory loss?
  • Does Zerolip 20 mg Tablet make you tired?
  • Can Zerolip 20 mg Tablet be prescribed to children?
  • Is Zerolip 20 mg Tablet a blood thinner?
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