Zodef 6 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 200.00

Medicine Details

Category	Details
Generic	Deflazacort
Company	Renata limited
Also available as	Zodef 6 mg tablet Zodef 24 mg tablet Zodef 30 mg tablet Zodef 36 mg tablet Zodef 18 mg tablet

Anaphylaxis, asthma, severe hypersensitivity reactions
Rheumatoid arthritis, juvenile chronic arthritis, polymyalgia rheumatica
Systemic lupus erythematosus, dermatomyositis, mixed connective tissue disease (other than systemic sclerosis), polyartritis nodosa, sarcoidosis
Pemphigus, bullous pemphigoid, pyoderma gangrenosum
Minimal change nephrotic syndrome, acute interstitial nephritis
Rheumatic carditis
Ulcerative colitis, Crohn's disease
Uveitis, optic neuritis
Autoimmune haemolytic anaemia, idiopathic thrombocytopenic purpura
Acute and lymphatic leukaemia, malignant lymphoma, multiple myeloma
Immune suppression in transplantation

Provides anti-inflammatory action by inhibiting Phospholipase A2 enzyme and decreases the release of certain chemicals important in the immune system

Adults:
- Up to 120 mg/day for acute disorders
- Maintenance doses in most conditions are within the range of 3-18 mg/day for rheumatoid arthritis
- In bronchial asthma, high doses of 48-72 mg/day may be needed for acute attacks, with maintenance doses titrated to the lowest dose that controls symptoms
- Starting doses estimated based on the ratio of 5 mg prednisone or prednisolone to 6 mg for other conditions
Children:
- Doses usually lie in the range 0.25-1.5 mg/kg/day
- Juvenile chronic arthritis usually requires maintenance dose between 0.25-1.0 mg/kg/day
- Nephrotic syndrome initial dose is usually 1.5 mg/kg/day followed by down titration according to clinical need
- Bronchial asthma requires initial dose between 0.25-1.0 mg/kg on alternate days
Deflazacort Withdrawal: Dose reduction should not be abrupt for patients who have received more than physiological doses of systemic corticosteroids for greater than 3 weeks

Metabolized in the liver, maintenance dose may need adjustment when co-administered with liver enzyme inducers or inhibitors

Hypersensitivity to or any of the ingredients, patients receiving live virus immunization

Pregnancy: Corticosteroids may increase the risk of intrauterine growth retardation
Nursing Mother: Infants of mothers taking higher doses may have a degree of adrenal suppression, but the benefits of breastfeeding likely outweigh any theoretical risk

Special caution and frequent patient monitoring required for cardiac disease or congestive heart failure, hypertension, thromboembolic disorders
Caution required for gastritis or oesophagitis, diverticulitis, ulcerative colitis, possibility of impending perforation, abscess or pyogenic infections, fresh intestinal anastomosis, active or latent peptic ulcer
Caution required for diabetes mellitus or family history, osteoporosis, myasthenia gravis, renal insufficiency
Caution required for emotional instability or psychotic tendency, epilepsy
Caution required for previous corticosteroid-induced myopathy, liver failure
Caution required for hypothyroidism and cirrhosis, which may increase the glucocorticoid effect
Ocular herpes simplex may pose risk of corneal perforation

Hepatic Impairment: Dose should be carefully monitored and adjusted to the minimum effective dose
Renal Impairment: No special precautions other than those usually adopted in patients receiving glucocorticoid therapy are necessary
Elderly: No special precautions other than those usually adopted in patients receiving glucocorticoid therapy are necessary

Glucocorticoids

Store in a cool (below 25°C) and dry place, protected from light & moisture, keep out of the reach of children