Pulmosis 267 mg (Tablet)
Unit Price: ৳ 45.00 (3 x 10: ৳ 1,350.00)
Strip Price: ৳ 450.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pirfenidone |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of Idiopathic Pulmonary Fibrosis (IPF) in adults
Pharmacology
- Anti-inflammatory properties
- Antioxidant properties
- Anti-fibrotic properties
- Improvement of lung function
- Reduction of acute exacerbations in IPF patients
- Suppression of TGF-β1
- Downregulation of pro-inflammatory cytokines
Dosage & Administration
- Oral administration with food
- Recommended daily dose of 2403 mg/day
- Titration schedule for initiating treatment
- Dose adjustments for gastrointestinal events
- Dose adjustments for photosensitivity reaction or rash
- Dose adjustments for hepatic function
Interaction
- Moderate and strong inhibitors of CYP1A2 increase systemic exposure
- Reduced incidence of adverse reactions observed in the fed group
Contraindications
- Hypersensitivity to the active substance or excipients
- Concomitant use of fluvoxamine
- Severe hepatic impairment or end stage liver disease
- Severe renal impairment (CrCl <30 ml/min) or end stage renal disease requiring dialysis
Side Effects
- Common: nausea, rash, abdominal pain, upper respiratory tract infection, diarrhea, fatigue, headache, dyspepsia, dizziness, vomiting, anorexia, gastroesophageal reflux disease, sinusitis, insomnia, weight decrease, arthralgia
- Rare: photosensitivity reaction, decreased appetite, pruritus, asthenia, dysgeusia, non-cardiac chest pain
Pregnancy & Lactation
- Precaution to avoid use during pregnancy
- Unknown excretion in human milk
- No effects on fertility and reproductive performance in animal studies
Precautions & Warnings
- Elevated liver enzymes monitoring
- Photosensitivity and rash precautions
- Gastrointestinal disorders precautions
Use in Special Populations
- Safety and efficacy in children & adolescents not known
- Monitoring and dosage modification for hepatic impairment
- Monitoring and dosage modification for renal impairment
- Altered exposure in smokers
Overdose Effects
- Limited clinical experience with overdose
- Mild, transient adverse reactions noted
Therapeutic Class
- Immunosuppressant
Storage Conditions
- Cool & dry storage
- Protection from light & moisture
- Keep out of reach of children