Dermova 0.05% (Cream)

10 gm tube: ৳ 58.00

Medicine Details

Category Details
Generic Clobetasol propionate
Company Nipro jmi pharma ltd
Also available as
Dermova 005 ointment

Indications

  • Psoriasis (excluding widespread plaque psoriasis)
  • Recalcitrant dermatoses
  • Lichen planus
  • Discoid lupus erythematosus
  • Other skin conditions which do not respond satisfactorily to less potent steroids

Composition

  • Clobetasol Propionate Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Scalp Application: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Shampoo: Each gram shampoo contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Lotion: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)
  • Clobetasol Propionate Spray: Each gram spray contains Clobetasol Propionate BP 0.5 mg (0.05% w/w)

Pharmacology

  • Very potent topical corticosteroid
  • Anti-inflammatory
  • Antipruritic
  • Vasoconstrictive properties
  • Inhibits late phase allergic reactions
  • Decreases mast cell density
  • Inhibits cytokine production

Dosage

  • Super-high potency topical corticosteroid
  • Treatment limited to 2 consecutive weeks
  • Maximum weekly dose should not exceed 50 gm/week
  • Total dose applied should not exceed 50 ml weekly for scalp application

Administration

  • Route of administration: Cutaneous

Interaction

  • Inhibition of CYP3A4 metabolism by co-administered drugs

Contraindications

  • Rosacea, acne vulgaris and perioral dermatitis
  • Hypersensitivity to the preparation
  • Primary cutaneous viral infections
  • Dermatoses in children under one year of age

Side Effects

  • Hypercorticism with prolonged use or extensive treatment
  • Local atrophic changes in the skin
  • Pustular form of psoriasis
  • Pigmentation changes and hypertrichosis
  • Hypersensitivity signs

Pregnancy & Lactation

  • Use only if benefit outweighs risk
  • Caution in nursing women

Precautions & Warnings

  • Avoid long-term continuous therapy, particularly in infants and children
  • Atrophic changes in the skin after prolonged treatment
  • Risk of glaucoma or cataract if applied to eyelids
  • Hazardous in psoriasis due to rebound relapses
  • Appropriate anti-microbial therapy for infected lesions

Use in Special Populations

  • Avoid long-term continuous therapy in infants and children under 12 years

Overdose Effects

  • Acute overdosage is unlikely
  • Features of hypercortisolism in chronic over-dosage

Therapeutic Class

  • Other Topical corticosteroids

Storage Conditions

  • Keep below 30°C
  • Protected from light and moisture
  • Do not freeze
  • Keep out of the reach of children

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