Dermova 0.05% (Ointment)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate |
| Company | Nipro jmi pharma ltd |
| Also available as |
Indications
- Psoriasis (excluding widespread plaque psoriasis)
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Other skin conditions which do not respond satisfactorily to less potent steroids
Composition
- Clobetasol Propionate Cream
- Clobetasol Propionate Ointment
- Clobetasol Propionate Scalp Application
- Clobetasol Propionate Shampoo
- Clobetasol Propionate Lotion
- Clobetasol Propionate Spray
Pharmacology
Very potent topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. Shows anti-inflammatory activity via multiple mechanisms and decreases the density of mast cells, chemotaxis, and activation of eosinophils. It also reduces cytokine production and inhibits the metabolism of arachidonic acid.
Dosage
- Cream, Ointment: Apply a thin layer twice daily to affected skin areas
- Spray: Apply required quantity once or twice daily to affected scalp areas
- Shampoo: Applied once a day to the dry scalp
- Scalp Solution: Apply required quantity once or twice daily to affected scalp areas
Administration
Route of administration: Cutaneous. Creams are appropriate for moist or weeping surfaces. Ointments are appropriate for dry, lichenified, or scaly lesions.
Interaction
Co-administered drugs that can inhibit CYP3A4 have been shown to inhibit the metabolism of corticosteroids leading to increased systemic exposure.
Contraindications
- Rosacea, acne vulgaris, and perioral dermatitis
- Primary cutaneous viral infections
- Hypersensitivity to the preparation
- The use of Clobetasol Propionate skin preparations in the treatment of primarily infected skin lesions caused by fungi or bacteria
- Dermatoses in children under one year of age
Side Effects
- Prolonged use of large amounts can result in hypercorticism
- Local atrophic changes in the skin
- Reports of pigmentation changes and hypertrichosis
- Exacerbation of symptoms may occur
Pregnancy & Lactation
Limited data from the use in pregnant women. Topical administration to pregnant animals can cause abnormalities of fetal development. Caution should be exercised during lactation.
Precautions & Warnings
- Long-term continuous therapy should be avoided, particularly in infants and children
- Atrophic changes may occur on the face after prolonged treatment
- Care is needed to ensure the preparation does not enter the eye if applied to the eyelids
- Topical corticosteroids may be hazardous in psoriasis for various reasons
Use in Special Populations
In infants and children under 12 years of age, long-term continuous therapy should be avoided where possible.
Overdose Effects
Acute overdosage is very unlikely, but in cases of chronic over-dosage, features of hypercortisolism may occur.
Therapeutic Class
Other Topical corticosteroids
Storage Conditions
Keep below 30°C, protected from light and moisture. Do not freeze. Keep out of the reach of children.