D-Met 500 mg (Tablet)

Unit Price: ৳ 4.00 (5 x 10: ৳ 200.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Ad din pharmaceuticals ltd
Also available as
D met 850 mg tablet

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of type 2 diabetes in overweight patients
  • Use in adults as monotherapy or in combination with other oral antidiabetic agents or with insulin
  • Use in children from 10 years of age and adolescents
  • Reduction of diabetic complications in overweight type 2 diabetic adult patients
  • First-line therapy after diet failure

Pharmacology

  • Oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action from sulfonylureas
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity
  • Increases peripheral glucose uptake and utilization

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses
  • Dosage increases in increments
  • Different dosage for adults and children
  • Different dosages for immediate release and extended release tablet
  • Dosage adjustment for renal impaired patients

Interaction

  • No information about chronic co-administration with Furosemide
  • Enhancement of absorption by Nifedipine
  • Potential interaction with cationic drugs eliminated by renal tubular secretion
  • No effect on Cimetidine pharmacokinetics
  • Drugs that can produce hyperglycemia

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Acute conditions altering renal function
  • Conditions causing tissue hypoxia

Side Effects

  • Blood and lymphatic system disorders
  • Metabolism and nutrition disorders
  • Nervous system disorders
  • Gastrointestinal disorders
  • Hepatobiliary disorders
  • Skin and subcutaneous tissue disorders

Pregnancy & Lactation

  • Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
  • Recommended use of insulin in pregnancy
  • Excretion into human breast milk
  • No adverse effects observed in breastfed newborns/infants
  • Breastfeeding not recommended during treatment

Precautions & Warnings

  • Substantial excretion by the kidney
  • Risk of D-Met accumulation and lactic acidosis
  • Lowering of vitamin B12 level
  • Increased risk of hypoglycemia
  • Regular renal function monitoring
  • Caution in conditions causing dehydration or serious infections
  • Annual estimation of Vitamin B-12 levels
  • Interaction with sulphonylurea and anticoagulants

Use in Special Populations

  • Adjusted dosage for elderly subjects
  • No effect on growth and puberty observed in controlled clinical studies
  • Recommended caution in prescribing to children aged between 10 and 12 years
  • Regular assessment of renal function
  • Exercise caution in situations where renal function may become impaired

Overdose Effects

  • No hypoglycemia observed with D-Met doses up to 85 gm
  • Lactic acidosis occurred in such circumstances
  • Medical emergency
  • Treatment in hospital
  • Hemodialysis for removal of lactate and D-Met

Therapeutic Class

Biguanides

Storage Conditions

Keep below 30°C temperature, protected from light & moisture, keep out of the reach of children

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