Dystolic 5 mg (Tablet)

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Nebivolol hydrochloride
Company Healthcare pharmaceuticals ltd
Also available as
Dystolic 25 mg tablet

Indications

  • Hypertension
  • Treatment of essential hypertension
  • Chronic heart failure (CHF)
  • Treatment of stable mild and moderate chronic heart failure in elderly patients.

Pharmacology

  • Beta adrenergic receptor blocking agent
  • Inhibition of beta1 and beta1 adrenergic receptors
  • Lack of intrinsic sympathomimetic and membrane stabilizing activity
  • Decreased heart rate
  • Decreased myocardia contractility
  • Diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers
  • Suppression of renin activity
  • Vasodilation and decreased peripheral vascular resistance
  • Metabolism by glucuronidation and hydroxylation by CYP2D6
  • Effective half-life of about 12-19 hours
  • Plasma protein binding of approximately 98%
  • Absorption similar to oral solution
  • Mean peak plasma nebivolol concentrations occur approximately 1.5 to 4 hours post-dosing
  • Predominantly metabolized via direct glucuronidation of parent
  • Excretion via urine and feces
  • CYP2D6 Inhibitors caution

Dosage & Administration

  • Recommended starting dose of 5 mg once daily
  • Dose increase at 2-week intervals up to 40 mg
  • Unlikely benefit from more frequent dosing regimen

Interaction

  • Use with care when myocardial depressants or inhibitors of AV conduction are used concurrently
  • Not to be combined with other beta-blockers
  • Closely monitor patients receiving catecholamine-depleting drugs
  • Use caution when co-administered with CYP2D6 inhibitors

Contraindications

  • Severe bradycardia
  • Heart block greater than first degree
  • Cardiogenic shock
  • Decompensated cardiac failure
  • Sick sinus syndrome
  • Severe hepatic impairment
  • Hypersensitivity to any component of the product

Side Effects

  • Headache
  • Nausea
  • Bradycardia

Precautions & Warnings

  • Abrupt cessation of therapy caution
  • Cardiac Failure caution
  • Angina and Acute Myocardial Infarction caution
  • Bronchospastic Diseases caution
  • Anesthesia and Major Surgery caution
  • Diabetes and Hypoglycemia caution
  • Thyrotoxicosis caution
  • Peripheral Vascular Disease caution
  • Non-dihydropyridine Calcium Channel Blockers caution

Use in Special Populations

  • Caution in patients with severe renal impairment
  • Caution in patients with moderate hepatic impairment
  • Risk of Anaphylactic Reactions caution

Therapeutic Class

  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep below 30°C temperature
  • Keep away from light & moisture
  • Keep out of the reach of children

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