Cardicam 2.5 mg (Tablet)

Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Bisoprolol hemifumarate
Company Belsen pharmaceuticals ltd
Also available as
Cardicam 5 mg tablet

Indications

  • Hypertension
  • Angina
  • Moderate to severe heart failure

Pharmacology

  • Selective Blocker: ß1
  • Affinity for ß1 receptor: High
  • Effects on heart rate: Reduction
  • Effects on cardiac output: Reduction
  • Arterial hypertension reduction mechanism: Vascular smooth muscle relaxation
  • Impact on lipid metabolism: No change in cholesterol fraction
  • Absorption rate from gastrointestinal tract: >90%
  • Bioavailability: 88%
  • Distribution volume: 3.51 L/kg
  • Metabolism: Oxidative pathways
  • Major metabolites: Renally eliminated
  • Clearance balance: Renal elimination and hepatic metabolism
  • Total clearance: Approximately 15 L/h
  • Elimination half-life: 10-12 hours

Dosage & Administration

  • Adult starting dose: 5 mg once daily
  • Maximum adult dose: 20 mg once daily
  • Dose titration interval: 2 weeks
  • Pediatric use: Safety and effectiveness not established
  • Renal or hepatic impairment dose caution: Initial dose 5 mg

Interaction

  • Combining with other β-blocking agents not recommended
  • Close monitoring with catecholamine-depleting drugs
  • Risk of exacerbating rebound hypertension with clonidine withdrawal
  • Use caution when coadministered with myocardial depressants

Contraindications

  • Cardiogenic shock
  • Overt heart failure
  • Second or third degree A-V block
  • Right ventricular failure from pulmonary hypertension
  • Sinus bradycardia

Side Effects

  • Fatigue
  • Dizziness
  • Headache
  • Gastrointestinal disturbances
  • Cold or numb extremities
  • Muscle weakness or cramps
  • Breathing difficulties

Pregnancy & Lactation

  • Teratogenic effects in rats: None at doses up to 150 mg/kg/day
  • Fetotoxic effects in rats: At 50 mg/kg/day
  • Maternotoxic effects in rats: At 150 mg/kg/day
  • Teratogenic effects in rabbits: None at doses up to 12.5 mg/kg/day
  • Embryolethal effects in rabbits: At 12.5 mg/kg/day
  • Use during pregnancy: Only if potential benefit justifies potential risk
  • Excretion in human milk: Not known

Precautions & Warnings

  • Use caution in patients with renal or hepatic impairment
  • Increased reactivity in patients with history of severe anaphylactic reaction
  • Potential unresponsiveness to usual doses of epinephrine

Therapeutic Class

Anti adrenergic agent (Beta blockers)

Storage Conditions

Dry place away from light and heat, Keep out of reach of children

Chemical Structure

  • Molecular Formula: C<sub>18</sub>H<sub>31</sub>NO<sub>4</sub>

Common Questions about Cardicam 2.5 mg Tablet

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